Ventilation, inflammation, perfusion and structure in pediatric Bronchopulmonary dysplasia Erasmus
- Conditions
- Bronchopulmonary dysplasia
- Registration Number
- NL-OMON21082
- Lead Sponsor
- Erasmus MC- Sophia Children's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Diagnosis of BPD according to the NHI criteria, aged between 6-10 years, will have/has a CT scan planned within 6 months of this research, informed consent by parents (and patient).
Exclusion Criteria
Inability to undergo MRI, inability to follow instructions in the MRI, current severe lung infection (symptoms of respiratory distress, severe coughing, antibiotic use), chronic oxygen use
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcomes of this study are the pulmonary MR findings. All scans will be evaluated on changes in ventilation, inflammation, perfusion and structure. <br /><br>All data will be compared to the spirometry, LCI and MRI of two control groups: 1) premature non-BPD patients (born before <32 weeks without the diagnosis of BPD) 2) healthy volunteers.
- Secondary Outcome Measures
Name Time Method A qualitative and feasibility check of all MRIs will be done. Furthermore, all the MRI findings will be compared to the spirometry and multiple breath washout measurements and a clinically ordered pulmonary CT made within six months of the research MRI.