Ventilaton, inflammation, perfusion and structure in Neontale Lung patients

• Conditions: Bronchopulmonary dyslasia

• Registration Number: NL-OMON29625
• Lead Sponsor: Erasmus MC- Sophia Children's Hospital

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 18

Inclusion Criteria

Premature: born before 28 weeks PMA, good enough clinical condition to undergo MRI, parents manage Dutch language, informed consent by parents, at 34-40 weeks PMA: still admitted at the Sophia Children’s Hospital, severe BPD according to NHI criteria or at risk for severe BPD (received 28 days of oxygen therapy)
Non- premature: born at a minimum of 37 weeks PMA, good enough clinical condition for MRI, parents manage Dutch language, informed consent by parents

Exclusion Criteria

Premature:contraindication for MRI investigation, congenital cardiovascular or pulmonary abnormalities (other than caused by prematurity)
Non- premature:contraindication for MRI investigation, obtained mechanical ventilation, congenital cardiovascular or pulmonary abnormalities

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The technical qualitative assessment of the MRIs

Secondary Outcome Measures

Name	Time	Method
The ability of the MRI protocol to detect airway and lung ventilation, inflammation, perfusion and structural changes. Furthermore, the MRIs of prematurely born infants will be compared to the MRIs of non- premature patients without pulmonary disease. And lastly, the technical feasibility of MRI to detect cardiac structures will be assessed.