Ventilation Inflammation Perfusion and Structure in pediatric Bronchopulmonary Dysplasia Erasmus

Completed

Conditions: 10028971
underdeveloped lungs
Bronchopulmonary dysplasia

Registration Number: NL-OMON49241

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

Patients: diagnosis of BPD according to NHI criteria, age between 6 and 16
years, (in half of the BPD patients,n<=6) routine clinical CT scan planned in
the next six months or received a clinically ordered spirometry controlled CT
in the past six months, informed consent by parents/patient, Premature- non BPD
volunteers: age between 6 and 16 years, born <32 weeks of gestation, informed
consent by parents/patient, Healthy volunteers: age between 6 and 16 years,
informed consent by parents/patient

Exclusion Criteria

Patients: contra- indications for MRI, inability to follow instructions in the
MRI, current severe lung infection (respiratory distress, severe coughing,
antibiotic use for lung infection), chronic oxygen need, Premature non- BPD
patients: contra- indications for MRI, inability to follow instructions in the
MRI, current severe lung infection (respiratory distress, severe coughing,
antibiotic use for lung infection), chronic oxygen need, diagnosis of BPD,
Healthy volunteers: contra- indications for MRI, inability to follow
instructions in the MRI, current severe lung infection (respiratory distress,
severe coughing, antibiotic use for lung infection), chronic oxygen need, born
at a gestational age of less than 37 weeks, presence of pulmonary comorbidities
(asthma, cystic fibrosis, interstitial lung disease etc.)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main endpoint of this study is the ability of the MRI protocol to detect<br /><br>structural lung changes related to BPD as established using the VIBE- scoring<br /><br>system, evaluating normal lung tissue, low intensity regions, ventilation<br /><br>defects, presence of airway wall thickening, consolidations and severity of<br /><br>architectural distortion.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>A technical qualitative assessment of the MRIs will be done. The MRI findings<br /><br>will be correlated to spirometry data, MBW measurements and compared to the CT<br /><br>findings.</p><br>