Effect of Orange Juice on Glycemic Response

Not Applicable

Completed

• Conditions: Effect of Food on Postprandial Hyperglycemia
• Interventions: Other: test meal 1; Other: test meal 2; Other: control; Other: test meal 3

• Registration Number: NCT03522896
• Lead Sponsor: University of Leeds

Brief Summary

Orange juice naturally contains high concentrations of hesperidin, which affects glucose absorption in in vitro experiments. This study is to test if hesperidin and other components of orange juice (not other sugars or organic acids) affect the post-prandial blood glucose concentration derived from sugars already present in the orange juice.

Detailed Description

Healthy volunteers will consume orange juice with added water or food-grade hesperidin.

Study Timeline

• Study Start: 2017-09-30
• Study First Submitted: 2018-04-30
• Study First Submitted QC: 2018-05-10
• Study First Posted: 2018-05-11
• Status Verified: 2018-06
• Primary Completion: 2018-06-27
• Study Completion: 2018-06-27
• Last Update Submitted: 2018-06-27
• Last Update Posted: 2018-06-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• fasting blood glucose below 5.9 mM

Exclusion Criteria

• fasting glucose above 6 mM pregnant

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
test meal 1	test meal 1	orange juice with added hesperidin (low dose)
test meal 2	test meal 2	orange juice with added hesperidin (high dose)
control meal	control	glucose, fructose, sucrose, malic acid and citric acid in water
test meal 3	test meal 3	diluted orange juice with added hesperidin

Primary Outcome Measures

Name	Time	Method
Blood glucose concentration	3 hours	iAUC/\[glucose\]max

Trial Locations

Locations (1)

University of Leeds; 🇬🇧 Leeds, United Kingdom