Orange Juice Consumption and Glucose Metabolism and Antioxidative Status

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Orange juice with meals; Dietary Supplement: Orange juice between meals; Dietary Supplement: Sugar sweetened beverage between meals

• Registration Number: NCT02974478
• Lead Sponsor: University of Hohenheim

Brief Summary

Aim of the study is to investigate the impact of orange juice consumption (with meals or between meals) as well as sugar sweetened beverage (SSB) consumption (between meals) on glucose homeostasis and antioxidative status.

Detailed Description

Duration of the study is 3x three weeks including one wash-out week each followed by two weeks of juice/SSB consumption under free living conditions.

During wash-out weeks consumption of orange juice or citrus fruits is restricted.

During intervention weeks, participants are asked to eat three regular meals per day without snacking. Intervention weeks are (i) orange juice consumption with meals (ii) orange juice consumption between meals and (iii) SSB consumption between meals. Daily energy intake with orange juice/SSB is 20% of individual energy requirement. Additional caloric beverages (SSB, juice, coffee with sugar/milk, alcohol) are not allowed. At the beginning and the end of each intervention phase insulin sensitivity and antioxidative status are assessed.

Study Timeline

• Study Start: 2016-04
• Study First Submitted: 2016-11-02
• Study First Submitted QC: 2016-11-22
• Study First Posted: 2016-11-28
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Status Verified: 2017-04
• Last Update Submitted: 2017-04-22
• Last Update Posted: 2017-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• healthy

Exclusion Criteria

• regular use of medication,
• smoking,
• chronic disease,
• vegan/vegetarian diet,
• fructose intolerance,
• irregular eating behaviour (less then 3 meals/day)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Orange juice with meals	Orange juice with meals	Effect of orange juice consumption with three meals per day (without snacking) on glucose metabolism and antioxidative status
Orange juice between meals	Orange juice between meals	Effect of orange juice consumption between three meals per day (without snacking) on glucose metabolism and antioxidative status
Sugar sweetened beverage between meals	Sugar sweetened beverage between meals	Effect of sugar sweetened beverage consumption between three meals per day (without snacking) on glucose metabolism and antioxidative status

Primary Outcome Measures

Name	Time	Method
changes in daylong glycaemia between pre and post intervention periods	two weeks	measured via continuous glucose monitoring \[mg/dL\]

Secondary Outcome Measures

Name	Time	Method
changes in insulin sensitivity between pre and post intervention periods	two weeks	measured via "Matsuda-Index" from oral glucose tolerance test data
changes in uric acid between pre and post intervention periods	two weeks	measured via uric acid serum levels \[mg/dL\]
changes in antioxidative status between pre and post intervention periods	two weeks	measured via vitamin c blood levels \[mg/L\]

Trial Locations

Locations (1)

Institute of Nutritional Medicine, University of Hohenheim; 🇩🇪 Stuttgart, Germany