Effect of Hesperidin in Orange Juice on Glycemic Response in Healthy Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Blood glucose concentration
研究概览
简要总结
Orange juice naturally contains high concentrations of hesperidin, which affects glucose absorption in in vitro experiments. This study is to test if hesperidin and other components of orange juice (not other sugars or organic acids) affect the post-prandial blood glucose concentration derived from sugars already present in the orange juice.
详细描述
Healthy volunteers will consume orange juice with added water or food-grade hesperidin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •fasting blood glucose below 5.9 mM
排除标准
- •fasting glucose above 6 mM pregnant
研究组 & 干预措施
control meal
glucose, fructose, sucrose, malic acid and citric acid in water
干预措施: control (Other)
test meal 1
orange juice with added hesperidin (low dose)
干预措施: test meal 1 (Other)
test meal 2
orange juice with added hesperidin (high dose)
干预措施: test meal 2 (Other)
test meal 3
diluted orange juice with added hesperidin
干预措施: test meal 3 (Other)
结局指标
主要结局
Blood glucose concentration
时间窗: 3 hours
iAUC/\[glucose\]max
次要结局
未报告次要终点
研究者
Gary Williamson
Prof
University of Leeds