Predictive Value of Epicardial Adipose Tissue for Pulmonary Embolism and Death in Patients With Lung Cancer

Withdrawn

• Conditions: Lung Cancer; Pulmonary Embolism
• Interventions: Diagnostic Test: CTPA (computed tomography pulmonary angiography)

• Registration Number: NCT06017271
• Lead Sponsor: First Affiliated Hospital Xi'an Jiaotong University

Brief Summary

The occurrence and progression of lung cancer is related to visceral adipose tissue (VAT). Epicardial adipose tissue (EAT) is a kind of VAT, producing a variety of inflammatory cytokines and adipokines, participating in the formation of local inflammation, promoting the formation of pre-thrombotic state, and leading to the occurrence of thromboembolism. Patients with lung cancer have increased inflammatory response and are more prone to suffer thrombosis. However, in lung cancer patients, the clinical correlation between EAT and pulmonary embolism has not been reported. Objective: To analyze the risk factors of poor prognosis in lung cancer patients with PE, and to explore the predictive value of EAT in pulmonary embolism events and death in lung cancer patients. Methods: EAT volume and density, as well as anthropometric and blood biomarkers, were evaluated in a sample of lung cancer patients, half with pulmonary embolism and half without. The incidence of adverse prognosis and related factors were followed up by telephone.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-08-24
• Study First Submitted QC: 2023-08-24
• Study First Posted: 2023-08-30
• Study Start: 2024-05-01
• Status Verified: 2024-07
• Primary Completion: 2024-07-15
• Study Completion: 2024-07-19
• Last Update Submitted: 2024-07-19
• Last Update Posted: 2024-07-22

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• The pathological diagnosis was lung cancer
• Pulmonary artery was evaluated by CTA during hospitalization.

Exclusion Criteria

• Patients with incomplete clinical data
• Patients with no follow-up data
• Patients with a history of PE before diagnosis of lung cancer

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
control group	CTPA (computed tomography pulmonary angiography)	The CTPA diagnosis did not suggest pulmonary embolism
PE group	CTPA (computed tomography pulmonary angiography)	The CTPA diagnosis suggest pulmonary embolism

Primary Outcome Measures

Name	Time	Method
EAT volume	May, 20, 2023	volume of epicardial adipose tissue (EAT), Cm3
EAT density	May, 20, 2023	density of epicardial adipose tissue (EAT) , Hounsfield Units (HU)

Trial Locations

Locations (1)

First Affiliated Hospital of Xian Jiaotong University; 🇨🇳 Xi'an, Shaanxi, China