Study of Immune Responses to Influenza Vaccination

Phase 4

Recruiting

• Conditions: Influenza Vaccination
• Interventions: Biological: Influenza vaccination

• Registration Number: NCT03346772
• Lead Sponsor: University of Pennsylvania

Brief Summary

Better understanding of the immune responses to influenza vaccination is needed in order to understand situations of poor vaccine response. Adults will receive influenza vaccination and then have peripheral blood drawn at pre-defined intervals in order to study the lymphocyte responses.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-10-20
• Study First Submitted: 2017-11-14
• Study First Submitted QC: 2017-11-16
• Study First Posted: 2017-11-17
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-27
• Last Update Posted: 2024-08-28
• Primary Completion: 2025-07-01
• Study Completion: 2026-07-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Community-dwelling adults able to provide consent who need influenza vaccination for standard of care

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Exclusion Criteria

• febrile illness at time of vaccination
• active malignancy
• use of immunosuppressing medications
• blood donation in the past 60 days
• influenza vaccinated during the preceding 6 months
• allergic reactions to influenza vaccination

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Influenza vaccination cohort	Influenza vaccination	Adults will receive one intramuscular dose of seasonal quadrivalent inactivated influenza vaccine, as indicated for standard of care.

Primary Outcome Measures

Name	Time	Method
Influenza neutralizing antibody titers	21-42 days

Trial Locations

Locations (1)

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States