A study comparing brain cooling method of conventional vs additional nasal cooling on aortic root surgery
Not Applicable
- Conditions
- Surgery on the ascending aorta/proximal aortic archSurgery
- Registration Number
- ISRCTN11167616
- Lead Sponsor
- niversity Hospital of South Manchester NHS Foundation Trust (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
1. All patients undergoing elective proximal aortic arch surgery with deep hypothermia circulatory arrest
2. Patients who have given written informed consent to take part in this study
Exclusion Criteria
1. Patients who are not undergoing deep hypothermia circulatory arrest
2. Patients undergoing emergency operations
3. Refusal to take part in the study
4. Patients who have a history of epistaxis (nasal bleeding) requiring hospital intervention
5. Patients who have a history of nasal obstruction
6. Patients who have a history of deviated nasal septum
7. Patients who have a history of coagulopathy
8. Patients who have a history of liver dysfunction
9. Patients who have a history of renal dysfunction and also less than GFR 30
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assess if transnasal brain cooling has any effect on reducing postoperative neurological dysfunction
- Secondary Outcome Measures
Name Time Method <br> 1. Assess the effect of transnasal brain cooling on:<br> 1.1. Early mobilisation<br> 1.2. Length of hospital stay<br> 1.3. Requirement of sedative medications for confusion and delirium<br> 2. Assess the effect on brain and core temperature trends when trans-nasal brain cooling is used prior to and during deep hypothermia<br>