Periodontal Therapy in Coronary Artery Patients

Not Applicable

Completed

• Conditions: Coronary Artery Disease; Cardiovascular Diseases; Atheroma
• Interventions: Device: Oral prophylaxis; Device: Subgingival scaling and root planing

• Registration Number: NCT01609725
• Lead Sponsor: Federal University of Rio Grande do Sul

Brief Summary

Gingival inflammation has been associated with cardiovascular diseases, including heart attack and stroke, because of elevation of blood risk markers such as cholesterol, glucose and C reactive protein. The treatment of gingival diseases decreases the concentration of these risk factors in the blood of cardiovascular patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-05-29
• Study First Submitted QC: 2012-05-29
• Study First Posted: 2012-06-01
• Primary Completion: 2016-07
• Study Completion: 2017-12
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-26
• Last Update Posted: 2019-10-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 93

Inclusion Criteria

• 35 years and older
• coronary artery disease
• more than 10 teeth
• chronic periodontitis defined as 2 non-adjacent teeth with probing depth 5+mm and periodontal attachment loss 4+mm

Exclusion Criteria

• use of antibiotics in the last 6 months
• periodontal therapy in the last 12 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Community treatment	Oral prophylaxis	Control treatment group
Comprehensive treatment	Subgingival scaling and root planing	Test treatment group

Primary Outcome Measures

Name	Time	Method
Changes in flow-mediated dilation	Baseline, 1, 3 and 6 months
Changes in C reactive protein	Baseline, 3, 6 and 12 months

Secondary Outcome Measures

Name	Time	Method
Changes in Interleukin 1B concentrations	Baseline, 3, 6, 12 months
Changes in Interleukin 6	Baseline, 3, 6, 12 months
Changes in TNF alpha	Baseline, 3, 6, 12 months
Changes in Interleukin 8	Baseline, 3, 6, 12 months
Changes in Cholesterol	Baseline, 3, 6, 12 months
Changes in Glycated hemoglobin	Baseline, 3, 6, 12 months
Changes in LDL/HDL	Baseline, 3, 6, 12 months
Changes in Fibrinogen	Baseline, 3, 6, 12 months

Trial Locations

Locations (1)

Federal University of Rio Grande do Sul, School of Dentistry and University Hospital; 🇧🇷 Porto Alegre, RS, Brazil