Evaluation of the effect of local administration of vitamin D3 on the maxillary canine retraction and the amount of external apical root resorption: A Prospective, Double blind, Split mouth randomized control clinical study

The study titled Evaluation of the Effect of Local Administration of Vitamin D3 on Maxillary Canine Retraction and External Apical Root Resorption is a prospective, double-blind, split-mouth, randomized controlled clinical trial. The primary objective is to assess the effect of intraligamentary Vitamin D3 injections on the rate of maxillary canine retraction. The trial will include patients undergoing orthodontic treatment that requires the retraction of maxillary canines. Each patient’s maxillary arch will be divided into experimental and control sides. The experimental side will receive Vitamin D3 injections which is diluted in lignocaine, while the control side will receive plain lignocaine. The study aims to determine whether Vitamin D3 can enhance the rate of tooth movement and reduce treatment duration, which is particularly beneficial for adult patients where bone metabolism is slower, leading to prolonged treatment durations. The study design ensures a high level of scientific rigor by using a randomized, double-blind approach, thereby reducing bias. Outcomes will be measured in terms of the rate of canine retraction, with regular follow-ups and measurements taken to ensure accurate results. This research could potentially lead to improved orthodontic treatment protocols, providing faster and more efficient outcomes for patients. The study will be conducted according to the 1975 Helsinki declaration guidelines revised in 2013. Statistical analysis will be done with SPSS version 22.0.