Hemodialysis-induced fall in myocardial perfusion: identification of dialysis-specific triggers

Completed

Conditions: cardiac perfusion
10082206

Registration Number: NL-OMON38123

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 8

Inclusion Criteria

Adult (age >=18 years) hemodialysis (HD) patients who have been treated with HD for at least three months. Patients must have an arterio-venous fistula without recirculation as established by routine Transonic flow measurements. Pre-HD weight at the first dialysis session of the week must be consistently >2 kg above target weight.

Exclusion Criteria

1. The absence of informed consent. 2. Inability to get echocardiographic windows of adequate quality. 3. Left ventricular ejection fraction <=30%. 4. Cardiac rhythm other than sinus rhythm including pacemaker rhythm; 5. ICD and/or artificial heart valve at any position. 6. Unstable angina pectoris. 7. The use of long-acting nitrates. 8. The use of beta-blockers for the indication angina pectoris. 9. Recent haemorrhage. 10. Inability to endure a horizontal position in the PET scanner for the time of the study sessions. 11. Pregnancy or suspicion of pregnancy.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter is the change in myocardial blood flow by 13N-NH3<br /><br>PET. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are the development of left ventricular (LV)<br /><br>regional wall motion abnormalities (akinesia/hypokinesia by PET and<br /><br>echocardiography), electrocardiographic (ECG) signs of ischemia, and laboratory<br /><br>parameters indicative of ischemia (cTnT, cTnI) and inflammation (CRP).</p><br>