Hemodialysis-associated left ventricular dysfunction: identification of dialysis-induced triggers, prevalence and prognostic impact.

Conditions: Left ventricular dysfunction
left ventricular wall motion abnormality
10082206
10046447

Registration Number: NL-OMON33776

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 120

Inclusion Criteria

Adult (age >=18 years old) maintenance hemodialysis patients.

Exclusion Criteria

Pre-existing severe (New York Heart Association class IV) left ventricular systolic failure or inadequate echocardiographical windows to obtain images of sufficient quality.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The prevalence of HD-associated LV dysfunction as assessed by pre-, intra-, and<br /><br>post-HD echocardiography.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To elucidate the mechanisms/ pathways that are pathophysiologically involved in<br /><br>HD-associated LV dysfunction we will relate its occurrence to pre-HD levels and<br /><br>intra-HD alterations in biomarkers of the inflammatory response (hsCRP, IL-6,<br /><br>pentraxin III), oxidative stress (SOD, MDA, AGEs), bioincompatibility<br /><br>(complement, leukocytes), endothelial dysfunction/ activation (von Willebrand<br /><br>factor), and with autonomic dysfunction (HRV). The choice for these pathways is<br /><br>based on their likely role in both the regulation of MBF and the increased risk<br /><br>of adverse cardiac events. Finally, we will evaluate the outcome of this cohort<br /><br>during a 2-year follow-up and analyse for the prognostic impact of LV<br /><br>dysfunction on predefined cardiovascular events and changes in LV function by<br /><br>repeat echocardiography at 1 year and at 2 years.</p><br>