Characterisation of lipoproteins from patients with preeclampsia compared to healthy, pregnant and healthy, non-pregnant wome

• Conditions: Pre-eclampsia; preeclampsia; O14

• Registration Number: DRKS00005368
• Lead Sponsor: niversitätklinikum Freiburg Institut für Klinische Chemie und Laboratoriumsmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-11-05
• Study Completion: 2017-02-10
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 155

Inclusion Criteria

Group 1 (case): Pregnant women with preeclampsia according to the criteria of the German Society of Gynaecology and Obstetrics: hyptertension in pregancy (RR>140/90mmHg) and proteinuria (>300 mg/24h) occuring after the 20th week of pregnancy. Preeclampsia can also be diagnosed without proteinuria if fetal growth restriction, liver involvement, renal insufficiency, neurological dysfunctions or hematological disorders are observed after the 20th week of pregnancy. Informed consent. Age >18 years. Group 2 (control): for every individual from group 1 a healthy, pregnant women in matching gestational age (+/- 1 week). Informed consent. Age > 18 years. Group 3 (control): Healthy, non pregnant women. Informed consent. Age > 18 years and < 45 years.

Exclusion Criteria

Group 1 (case): lack of informed consent. Group 2 and 3 (controls): lack of informed consent. By anamnesis detection of: arterial hypertension, treatment with antihypertensive agents and other cardiac drugs, diabetes mellitus, renal insufficiency, lipid disorders, liver diseases.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of lipidvalues from ultracentrifugation process and subsequent enzymatic measurement. Exploratory analysis of results, therefore no further specification of endpoints possible.

Secondary Outcome Measures

Name	Time	Method
Comparison of the influence of different lipoproteinfraction obtained from ultracentrifugation process on vasoactive receptors and their second messengers in cell culture models. Exploratory analysis of results, therefore no further specification of endpoints possible.