Prospective investigation of clinical, lipidological, vascular and hepatic parameters with regard to cardiovascular risk factors and primary prevention in childhood
Recruiting
- Registration Number
- DRKS00031182
- Lead Sponsor
- Goethe Universität, Klinikum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
• Written consent to participate
• Age at birth and < 20 years of age
Exclusion Criteria
• Age = 20 years at the start of the study
• Acute illness
• other chronic diseases or infections (e.g. HIV, TB)
• Pregnancy
• Known alcohol, drug and/or medication abuse
• Parental Inability to Informed Consensus
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The first expectation is that a preventive examination with identification of pathological lipid constellations in childhood allows for an improved early risk characterization with regard to cardiovascular complications. For this purpose, the analysis of the sdLDL cholesterol, the Lp(a) isoforms, apolipoprotein B, adiponectin and CK18F is included in this analysis.
- Secondary Outcome Measures
Name Time Method Our second expectation is that in different risk groups as well as in individual different diseases, characteristic findings of the outcomes will be available early and expect that these will differ in patients with type 1 diabetes mellitus, in familial hypercholesterolemia and in cancer survivors.