临床试验/NCT02451904

NCT02451904已完成不适用

Microvascular and Metabolic Dysregulation in the Pathogenesis of Severe and Cerebral Malaria Investigated Through Host Metabolomics

University of Oxford1 个研究点分布在 1 个国家目标入组 840 人开始时间: 2015年6月最近更新: 2018年6月20日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: University of Oxford
入组人数: 840
试验地点: 1
主要终点: Characterisation of patterns of metabolic dysregulation in severe malaria

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies.
Despite treatment between 10-30% of patients with severe malaria die.
Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood.
Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.

研究设计

研究类型: Observational
观察模型: Case Control
时间视角: Prospective

入排标准

年龄范围: 12 Years 至 —（Child, Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

未提供

排除标准

•Known pre-existing chronic medical conditions including advanced hepatic disease.

结局指标

主要结局

Characterisation of patterns of metabolic dysregulation in severe malaria

时间窗: 4-6 weeks

Interrelationship between disturbances in metabolic pathways associated with acidosis and cerebral malaria

次要结局

未报告次要终点

研究者

发起方

University of Oxford

申办方类型

Other

责任方

Sponsor

研究点 (1)

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