Severe and Cerebral Malaria Investigated Through Host Metabolomics
- Conditions
- Severe Malaria
- Interventions
- Other: Observation
- Registration Number
- NCT02451904
- Lead Sponsor
- University of Oxford
- Brief Summary
* The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies.
* Despite treatment between 10-30% of patients with severe malaria die.
* Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood.
* Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 840
Not provided
- Known pre-existing chronic medical conditions including advanced hepatic disease.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Acidosis Observation Intensive monitoring Encephalitis Observation Intensive monitoring Sepsis Observation Intensive monitoring Severe/Cerebral Malaria Observation Intensive monitoring Uncomplicated Malaria Observation Intensive monitoring Healthy Individuals Observation Monitoring
- Primary Outcome Measures
Name Time Method Characterisation of patterns of metabolic dysregulation in severe malaria 4-6 weeks Interrelationship between disturbances in metabolic pathways associated with acidosis and cerebral malaria
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Chittagong Medical College Hospital (CMCH)
🇧🇩Chittagong, Bangladesh