Severe and Cerebral Malaria Investigated Through Host Metabolomics

Completed

• Conditions: Severe Malaria

• Registration Number: NCT02451904
• Lead Sponsor: University of Oxford

Brief Summary

* The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies.

* Despite treatment between 10-30% of patients with severe malaria die.

* Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood.

* Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-05-15
• Study First Submitted QC: 2015-05-19
• Study First Posted: 2015-05-22
• Study Start: 2015-06
• Primary Completion: 2017-09
• Study Completion: 2017-09
• Status Verified: 2018-06
• Last Update Submitted: 2018-06-19
• Last Update Posted: 2018-06-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 840

Inclusion Criteria

Not provided

Exclusion Criteria

• Known pre-existing chronic medical conditions including advanced hepatic disease.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Characterisation of patterns of metabolic dysregulation in severe malaria	4-6 weeks	Interrelationship between disturbances in metabolic pathways associated with acidosis and cerebral malaria

Trial Locations

Locations (1)

Chittagong Medical College Hospital (CMCH); 🇧🇩 Chittagong, Bangladesh