Role of alpha-defensin produced by intestinal Paneth cells in heart failure
Not Applicable
Recruiting
- Conditions
- Chronic heart failure
- Registration Number
- JPRN-UMIN000032796
- Lead Sponsor
- Hokkaido University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1) A patient with active inflammation 2) A patient who is taking antibiotics or has a history of taking antibiotics within the past 1 month 3) A patient with inflammatory bowel disease 4) A patient taking steroid or anti-immunosuppressant medicine 5) A patient with malignant disease whose life expectancy is less than a year 6) A patient who has a plan of hospitalization due to scheduled examination or treatment within a year 7) A patient with ventricular assist device (VAD)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fecal and blood alpha-defensin (HD5) originated from intestinal Paneth cells
- Secondary Outcome Measures
Name Time Method Gut microbiota, systemic inflammation, systemic oxidative stress, rates of cardiovascular events (all-cause death, heart failure-related death, all-cause hospitalization, hospitalization for worsening heart failure) etc.