Caloric Restriction, Exercise, and Glucoregulation in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 69
- 试验地点
- 2
- 主要终点
- Glucoregulatory function
研究概览
简要总结
Weight loss induced by caloric restriction alone (CR) and by exercise alone (EX) result in similar effects on blood glucose and insulin. The purpose of this study is to assess the hypothesis that weight loss through caloric restriction plus exercise will result in greater improvements on glucose tolerance and insulin action than similar weight losses through CR or EX alone.
详细描述
Participants are randomized into caloric restriction, exercise, and caloric restriction plus exercise weight loss groups. Measurements of blood glucose and insulin, oral glucose tolerance, and matched glucose infusion will be done at baseline and after weight loss of 6% of body weight. Other tests include maximal oxygen uptake (VO2max), strength tests, blood pressure, blood lipids, serum inflammatory markers, dual X-ray absorptiometry (DEXA) for bone density and body composition, physical activity levels, dietary intakes, and measures of arterial stiffness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •females postmenopausal
- •no diabetes, cardiovascular disease, cancer
- •no orthopedic problems
- •not currently exercising
- •BMI between 25 and 29.9
- •nonsmokers
排除标准
- •current regular exercisers
- •premenopausal women
- •cardiovascular disease, lung disease, cancer, diabetes
结局指标
主要结局
Glucoregulatory function
时间窗: 3-4 months
次要结局
未报告次要终点
研究者
Edward Weiss, Ph.D.
Associate Professor
St. Louis University