Diet for Dads Sperm: The effect of a dietary intervention on sperm function in men with obesity.

Not Applicable

Completed

• Conditions: Obesity: BMI over 30kg/m2; Male infertility; Low-nutrient diet.; Reproductive Health and Childbirth - Fertility including in vitro fertilisation; Diet and Nutrition - Obesity

• Registration Number: ACTRN12621001184864
• Lead Sponsor: Robinsons Research Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-03
• Study Completion: 2024-02-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 37

Inclusion Criteria

Obese defined by a BMI of greater than or equal to 30 kg/m2 and a waist circumference greater than 102cm.

Dietary confirmation of a suboptimal low nutrient diet as determined by the CSIRO Healthy Diet Score survey greater than or equal to 60 out of 100 (~80% of all Australian men). The diet scoring system assess the quantity, quality and variety of foods consumed, where an individual’s diet score reflecting their overall compliance with the Australian Dietary Guidelines, with a higher score reflecting better compliance.

Able to read and write English.

Exclusion Criteria

Prior vasectomy or vasectomy reversal.

Un-descendent testes and suspected pathologies related to sub-fertility (i.e. varicoceles) or known genetic disorders that effect weight and fertility (i.e. Klinefelter's Syndrome, Prader-Willi or Larence-Moon-Bardet-Biedel).

Cigarettes or illicit drug use.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sperm DNA damage (Halo Sperm) which is a visual assessment under a microscope[ At completion of the 12 weeks of intervention]

Secondary Outcome Measures

Name	Time	Method
Semen analysis - Sperm count, sperm motility and sperm morphology which is visualised under a light microscopy (composite)[ At completion of the 12 weeks of intervention];Reactive oxygen species in sperm by fluorescent probes measured on flow cytometery and point of care devices[ At completion of the 12 weeks of intervention]