The effect of probiotic supplementation on male infertility

Phase 2

Recruiting

• Conditions: Idiopathic oligoasthenoteratospermia.; Male infertility, unspecified; N46.9

• Registration Number: IRCT20230806059053N1
• Lead Sponsor: Kashan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 16 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Male
• Target Recruitment: 52

Inclusion Criteria

Definitive diagnosis of idiopathic oligoasthenospermia

Exclusion Criteria

People who take drugs affecting spermatogenesis such as tamoxifen, HCG, gonadotropin, androgens and cytotoxic drugs such as immunosuppressants, anticonvulsants, and antibiotic or antifungal drugs.
People who have a diet rich in probiotics.
People who have factors with a clear effect on the condition of asthenozoospermia include: varicocele, epididymovarcitis, prostatitis, history of testicular surgery, testicular trauma, testicular torsion, history of intracytoplasmic sperm injection (ICSI), history of chemotherapy, radiotherapy, abnormality. chromosomal abnormalities, cryptorchidism, hypogonadism, recent history of sexually transmitted diseases, pyospermia, smoking, alcohol, drugs, known hormonal disorders, diabetes, known liver and kidney disease, BMI over 30
Unwillingness to cooperate and participate in the study

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gene expression. Timepoint: Before the intervention and after the intervention. Method of measurement: Real-time PCR.

Secondary Outcome Measures

Name	Time	Method
Sperm concentration. Timepoint: Before the intervention and after the intervention. Method of measurement: Semen sample analysis.;Semen volume. Timepoint: Before the intervention and after the intervention. Method of measurement: Semen sample analysis.;Percentage of abnormal sperm morphology. Timepoint: Before the intervention and after the intervention. Method of measurement: Semen sample analysis.;Percentage of sperm motility. Timepoint: Before the intervention and after the intervention. Method of measurement: Semen sample analysis.;Percentage of sperm progressive motility. Timepoint: Before the intervention and after the intervention. Method of measurement: Semen sample analysis.;Total antioxidant capacity (TAC). Timepoint: Before the intervention and after the intervention. Method of measurement: ELISA.;Malondialdehyde (MDA) level. Timepoint: Before the intervention and after the intervention. Method of measurement: ELISA.