effect of ozone on low back pain.

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 64

Inclusion Criteria

Inclusion criteria including: Radicular LBP that persistent more than 6 weeks; Root impression due to disc bulging or foraminal narrowing that confirmable in MRI; The patient age must be between 18 -70 yr old; Physical status level I to II according to ASA physical status classification system. Valid, written consent to participate in study must be obtained; Pain score must be more than 4 according to numerical rating scale(NRS)tool; Lack of pain relieve to medication and physical therapy; Three or less nerve root must be involved.
Exclusion criteria including: If coagulopathy to exist; presence of systemic or zone of needle entry point infection; Severe anatomical distortion(for example scoliosis); presence history of back surgery or device implantation; Severe psychotic disorder is co-exist; history of allergy to local anesthetics is positive; if progressive deficiency or motor deficit to exist; If malignancy, pregnancy, or history of substance abuse, HIV and /or chronic hepatitis marker positive to exist; If acute trauma; or cauda equina syndrome to exist.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: befor itervention will started,and the end of weeks two and four months three and six. Method of measurement: Nnmrical Rating Scale tool of pain.;Chronic pain biomarker, TNFalpha in serum. Timepoint: befor itervention will started,and the end of month two. Method of measurement: Venous Blood sample.;Root Impression in MRI. Timepoint: Before intervention and the end of second month. Method of measurement: MRI imagine.

Secondary Outcome Measures

Name	Time	Method
Disability. Timepoint: befor intervention will start,the end of weeks two and four,months three and six. Method of measurement: Oswestry Disability Questionnaire.;Labratory data, BUN, Cr, Bs. Timepoint: befor intervention will start,the end of weeks two and four,months three and six. Method of measurement: Venous blood sample.;Dermatomal pain distribiotion,posetive SLR(and degree of), revres SLR. Timepoint: before intervention will start,the end of weeks two and four,month three and six. Method of measurement: Pain that induced with physical examination and it's distribution,degree of range of motion that induced pain,.