EUCTR2016-004222-42-FR进行中（未招募）1 期
Validation of the efficiency of repurposed drugs on the basis of their cellular transcriptomic signature, antagonist to that of the influenza A infection. - FLUNEXT
Centre Hospitalier Régional Universitaire de Lille0 个研究点目标入组 264 人开始时间: 2017年9月28日最近更新:
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 264
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
入选标准
- •Patients hospitalized in intensive care units, older than 18
- •- For a severe flu confirmed by positive PCR on nasopharyngeal
- •- Whose evolution is less than 96 hours,
- •- The severity of the flu is assessed by a respiratory failure
- •defined by the necessity to resort to mechanical ventilation,
- •invasive or not, or to deliver oxygen with a PaO2/FiO2<200
- •The inclusion is conditioned to the detection of Influenza A
- •viruses by rapid detection kit on nasopharyngeal swab.
- •- Written informed consent from patients or their relatives.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 264
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •- No consent.
- •- Hypersensibility to Oseltamivir.
- •- Negative rapid detection kit on nasopharyngeal swab.
- •- Symptoms for more than 96 hours.
- •- Moribund patients at admission.
- •- Contraindication to the molecules evaluated.
- •- Sinusal dysfonction without device.
- •- Auriculo-ventricular heart block without device.
- •- Cardiogenic pulmonary oedema.
- •- Bradycardia<40/min.
- •- Not treated coronary insufficiency.
- •- Ventricular arythmia.
- •- Hyperthryroidism.
- •- Non controlled hypertension.
- •- Obstructive cardiomyopathy.
- •- Heart valve stenosis.
- •- Pheochromocytoma.
- •-Concomitant use of beta-blockers, antiarythmic drugs,
- •especially amiodarone.
- •- Pregnant/nursing woman
- •- No social insurance cover
- •-Patient under a regim of juridic protection
研究者
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