Multicenter Normal Reference Study of Tissue Motion Tracking of Mitral Annular Displacement(TMAD)
- Conditions
- Healthy VolunteersLeft Ventricular Systolic Dysfunction
- Interventions
- Radiation: Echocardiography
- Registration Number
- NCT04399447
- Lead Sponsor
- Weidong Ren
- Brief Summary
To establish the range of TMADmid、TMADmidpt% by using tissue motion tracking of mitral annular displacement (TMAD), and to explore the influencing factors.
- Detailed Description
With the gradual aging of Chinese population and continuous development of economy and society, the incidence of cardiovascular disease and the number of patients have increased rapidly. The National Heart Center has reported that the number of patients with clinically diagnosed cardiovascular disease in China has reached 290 million in 2016 (240 million in 2014). Cardiovascular disease is the most common cause of death in humans. Left ventricular systolic function plays an important role in the treatment and prognosis of patients with myocardial diseases. Early sensitive detection of left ventricular systolic function, timely treatment and early evaluation of the therapeutic effect can greatly reduce the death of patients with myocardial diseases rate.
At present, the left ventricular ejection fraction (LVEF), measured by the two-plane Simpson method in clinical, is one of the methods to evaluating left ventricular systolic function. It is especially suitable for patients with geometric deformation of the left ventricle, but some early heart failure patients' LVEF is still in the normal range, whose systolic function has been reduced, but. In recent years, 2D longitudinal strain is one of the indicators for evaluating left ventricular systolic function. The researchers believe that 70% of cardiac function is obtained by longitudinal movement of myocardium , which can be used as a good indicator for identifying myocardial diseases. However, both the two-plane Simpson method and the 2D longitudinal strain require good sound transmission conditions and good image quality. You can clearly see the endocardium and epicardium. Not all of patients in the clinic can get better image.
Basic and clinical studies and clinical statistics show that tissue motion tracking of mitral annular displacement (TMAD) is not affected by image quality and can effectively evaluate left ventricular systolic function. It can measure the mitral valve annulus displacement by marking the mitral valve annulus point and the reference point, which can quickly and accurately evaluate the left ventricular longitudinal contraction function.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 2400
- Han nationality
- Ages 18-79.
- Normal body mass index (18-25kg / m2).
- Normal blood pressure (139-90 / 89-60mmHg).
- No history of cardiovascular and respiratory diseases.
- No abnormality was found in physical examination of cardiovascular and respiratory system.
- Blood glucose, lipid profile and electrocardiogram were normal.
- Echocardiography showed no structural heart disease and normal heart function.
- No history of medications affecting cardiovascular system.
- Clinically significant or moderate heart valve regurgitation.
- Respiratory diseases: acute or chronic respiratory diseases.
- Endocrine diseases: thyroid disease, diabetes, hyperaldosteronism, pheochromocytoma, and abnormal adrenal function.
- Anemia.
- Pregnant or lactating women.
- Abnormal liver function (glutamyl aminotransferase exceeds 2.0 times the upper limit of normal value), abnormal renal function (creatinine exceeds the normal value), increased blood lipids (triglycerides, total cholesterol, low density and high density lipoprotein, any of which is higher than Normal value).
- Connective tissue disease.
- Tumor.
- Aortic and peripheral vascular diseases: aortic dilatation, aortic dissection, aortic constriction, multiple arteritis, and atherosclerosis.
- Drink more than 50ml of white wine daily; more than 100ml of red wine; more than 300ml of beer.
- Professional athletes.
- The poor quality of the ultrasound image cannot satisfy the parameter measurement and analysis.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description 30-39 year-old group Echocardiography Based on the inclusion crtiteria, 200 healthy Han people at aged 30-39 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained. 18-29 year-old group Echocardiography Based on the inclusion crtiteria, 200 healthy Han people at aged 18-29 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained. 60-69 year-old group Echocardiography Based on the inclusion crtiteria, 200 healthy Han people at aged 60-69 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained. 70-79 year-old group Echocardiography Based on the inclusion crtiteria, 200 healthy Han people at aged 70-79 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained. 50-59 year-old group Echocardiography Based on the inclusion crtiteria, 200 healthy Han people at aged 50-59 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained. 40-49 year-old group Echocardiography Based on the inclusion crtiteria, 200 healthy Han people at aged 40-49 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained.
- Primary Outcome Measures
Name Time Method left ventricular systolic function was measured by tissue motion tracking of mitral annular displacement（TMAD） 1 day To establish the range of TMADmidpt% by using TMAD
- Secondary Outcome Measures
Name Time Method left ventricular systolic function was measured by the two-plane Simpson method 1 day the left ventricular ejection fraction measured by the two-plane Simpson method, is the standard of the clinical
Trial Locations
- Locations (75)
Anhui Provincial Hospital
🇨🇳Hefei, Anhui, China
Chongqing University Cancer Hospital
🇨🇳Chongqing, Chongqing, China
The People's Hospital of Gaozhou
🇨🇳Gaozhou, Guangdong, China
Qingyuan People's Hospital
🇨🇳Qingyuan, Guangdong, China
People'S Hospital of Baise
🇨🇳Baise, Guangxi, China
Guigang City People'S Hospital
🇨🇳Guigang, Guangxi, China
Guangxi International Zhuang Medical Hospital
🇨🇳Nanning, Guangxi, China
The first peopel's hospital of yulin
🇨🇳Yulin, Guangxi, China
Fengning Manchu Autonomous County Hospital
🇨🇳Chengde, Hebei, China
Handan First Hospital
🇨🇳Handan, Hebei, China
Tangshan fengnan district hospital
🇨🇳Tangshan, Hebei, China
Xingtai Third Hospital
🇨🇳Xingtai, Hebei, China
Nanyang Second People's Hospital
🇨🇳Nanyang, Henan, China
People'S Hospital of Hunan Province
🇨🇳Changsha, Hunan, China
The First People's Hospital of Huaihua
🇨🇳Huaihua, Hunan, China
Jiujiang University Affiliated Hospital
🇨🇳Jiujiang, Jiangxi, China
Baicheng Central Hospital
🇨🇳Baicheng, Jilin, China
Jilin Central General Hospital
🇨🇳Jilin, Jilin, China
The First Affiliated Hospital of Dalian Medical University
🇨🇳Dalian, Liaoning, China
Benxi Central Hospital
🇨🇳Benxi, Liaoning, China
Chaoyang Central Hospital
🇨🇳Chaoyang, Liaoning, China
Dalian Municipal Central Hospital
🇨🇳Dalian, Liaoning, China
The Second Affiliated Hospital of Dalian Medical University
🇨🇳Dalian, Liaoning, China
Fuchun Central Hospital
🇨🇳Fushun, Liaoning, China
General Hospital of Fushun Mining Bureau
🇨🇳Fushun, Liaoning, China
The First Affiliated Hospital of Jinzhou Medical University
🇨🇳Jinzhou, Liaoning, China
Shengjing Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
Central Hospital Affiliated To ShenYang Medical College
🇨🇳Shenyang, Liaoning, China
Hanzhong Central Hospital
🇨🇳Hanzhong, Shanxi, China
the Second Affiliated Hospital Of Shenyang Medical College
🇨🇳Shenyang, Liaoning, China
Zibo City Linzi District People's Hospital
🇨🇳Zibo, Shandong, China
Shaanxi Provincial People'S Hospital
🇨🇳Xi'an, Shanxi, China
The First Affiliated Hospital of Xi'an Jiaotong University
🇨🇳Xi'an, Shanxi, China
The Second Affiliated Hospital of Xi'an Jiaotong University
🇨🇳Xi'an, Shanxi, China
Xianyang Central Hospital
🇨🇳Xianyang, Shanxi, China
The Peoplep'S Hospital of Wenjiang District,Chengdu
🇨🇳Chendu, Sichuan, China
Chengdu Second People'S Hospital
🇨🇳Chengdu, Sichuan, China
Chengdu Third People's Hospital
🇨🇳Chengdu, Sichuan, China
West China-Guang'An Hospital,Sichuan University
🇨🇳Guang'an, Sichuan, China
The Affiliated Hospital of Southwest Medical University
🇨🇳Luzhou, Sichuan, China
Affiliated Hospital of North Sichuan Medical College
🇨🇳Nanchong, Sichuan, China
Nanchong Central Hospital
🇨🇳Nanchong, Sichuan, China
Panzhihua Central Hospital
🇨🇳Panzhihua, Sichuan, China
Suining Central Hospital
🇨🇳Suining, Sichuan, China
First Affiliated Hospital,School of Medical,Shihezi University
🇨🇳Shihezi, Xinjiang, China
Urumqi Friendship Hospital
🇨🇳Urumqi, Xinjiang, China
The First People's Hospital of Foshan City
🇨🇳Foshan, Guangdong, China
Gansu Baiyin Second People's Hospital
🇨🇳Baiyin, Gansu, China
the Second Affiliated Hospital of Guangzhou University of Chinese Medicine
🇨🇳Guangzhou, Guangdong, China
Affiliated Hospital of YouJiang Medical University for Nationalities
🇨🇳Baise, Guangxi, China
The People'S Hospital of Chong Zuo
🇨🇳Chongzuo, Guangxi, China
Laibin People's Hospital
🇨🇳Laibin, Guangxi, China
Guangxi Minzu Hospital
🇨🇳Nanning, Guangxi, China
The First Affiliated Hospital of Hainan Medical University
🇨🇳Haikou, Hainan, China
shijiazhuang No.1 Hospital
🇨🇳Shijiazhuang, Hebei, China
The Fourth Hospital of Heibei Medical University Hebei Cancer Hospital
🇨🇳Shijiazhuang, Hebei, China
Mudanjiang Cardiovascular Hospital
🇨🇳Mudanjiang, Heilongjiang, China
The Third Affiliated Hospital of Qiqihar Medical Hospital
🇨🇳Qiqihar, Heilongjiang, China
The Affiliated Hospital of Inner Mongolia Medical University
🇨🇳Hohhot, Inner Mongolia, China
The First Affiliated Hospital of Baotou Medical College
🇨🇳Baotou, Inner Mongolia, China
DanDong central hospital
🇨🇳Dandong, Liaoning, China
The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
🇨🇳Shenyang, Liaoning, China
The People'S Hospital of Liaoning Province
🇨🇳Shenyang, Liaoning, China
Qinghai Provincial People's Hospital
🇨🇳Xining, Qinghai, China
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, Ningxia, China
The Second Hospital of Shandong University
🇨🇳Jinan, Shandong, China
Liaocheng People'S Hospital
🇨🇳Liaocheng, Shandong, China
Yantai Affiliated Hospital of Binzhou Medical University
🇨🇳Yantai, Shandong, China
Baoji Central Hospital
🇨🇳Baoji, Shanxi, China
Shanghai Pudong New District Zhoupu Hospital
🇨🇳Shanghai, Shanghai, China
Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
🇨🇳Chengdu, Sichuan, China
Chengdu First People's Hospital
🇨🇳Chengdu, Sichuan, China
The People's Hospital Of Leshan
🇨🇳Leshan, Sichuan, China
Dali Bai Autonomous Prefecture People'S Hospital
🇨🇳Dali, Yunnan, China
The First Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China