Detection of novel genetic variants within the aquaporins 1 and 5
Completed
- Conditions
- Aquaporines, cell migration and inflammationRespiratoryAdult respiratory distress syndrome
- Registration Number
- ISRCTN55161632
- Lead Sponsor
- German Research Council (Deutsche Forschungsgemeinschaft [DFG]) (Germany)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 650
Inclusion Criteria
1. Acute respiratory distress syndrome:
1.1. Timing: acute onset
1.2. Oxygenation: partial pressure of oxygen in arterial blood (PaO2)/fraction of inspired oxygen (FiO2) ratio less than 200 mmHg (regardless of positive end expiratory pressure [PEEP])
1.3. Chest radiograph: bilateral infiltrates seen on frontal chest radiograph
1.4. Pulmonary artery wedge (PAW): less than 18 mmHg when measured or no clinical evidence of left atrial hypertension
2. Lung function testing with body plethysmography-revealed bronchial asthma
3. Patients with severe sepsis
4. Aged 18 to 70 years, both genders
Exclusion Criteria
No written informed consent is obtained
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Detection of SNPs wthin the Aqquaporin 1 and 5 gen which contribute to the phenotypic variability of ARDS, sepsis and bronchial asthma, measured at 30 day survival and 100 day survival
- Secondary Outcome Measures
Name Time Method Analysis of survival, disease course and rehabilitation, measured at 30 day survival and 100 day survival