Comparisons of the Dynamic of the Cardiorespiratory System Behavior of Extreme Preterm Infants Receiving Nasal CPAP or High Flow Nasal Cannula During the Immediate Post-extubation Period
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Differences on Heart Rate Variability in extremely preterm infants receiving HFNC and NCPAP
研究概览
简要总结
To avoid or decrease the rate of complications in preterm infants after disconnection from a mechanical ventilation (extubation), non-invasive respiratory support is routinely used. While infants are most commonly extubated to nasal continuous positive airway pressure (NCPAP), high flow nasal cannula (HFNC) has emerged as an attractive alternative. However, research regarding the safety and efficacy of HFNC in the most extreme preterm infants is limited. Therefore, we hypothesize that immediately after extubation, measures of heart rate and respiratory behavior may be useful to investigate for any differences between HFNC and NCPAP.
详细描述
Infants will be studied 30 min after extubation on both modes of support, provided in a random order. A transition period of 15 min between modes will be given. For each mode, recordings will be performed for 40 minutes. Analysis of these recordings will be done off line.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Infants with birth weight ≤ 1250 grams
- •Infants that have been mechanically ventilated and undergoing their first elective extubation attempt
排除标准
- •Major congenital anomalies, neuromuscular disease, hemodynamic instability (use of vasopressors or hypotension).
- •Infants reintubated before initiation or during data collection.
- •Parental/legal guardian consent not obtained.
结局指标
主要结局
Differences on Heart Rate Variability in extremely preterm infants receiving HFNC and NCPAP
时间窗: Immediate post-extubation period
Cardiac signals from the electrocardiogram will be continuously measured throughout the recordings. Analysis of these signals will be performed offline to calculate heart rate variability using linear and nonlinear methods.
Differences on Respiratory Variability in extremely preterm infants receiving HFNC and NCPAP
时间窗: Immediate post-extubation period
Respiratory variability will be calculated by using analysis of respiratory inductive pletysmography signals from the recordings during HFNC and NCPAP. Desaturation events will also be calculated from these recordings.
次要结局
未报告次要终点
研究者
Guilherme Sant'Anna, MD
Associate Professor, Department of Paediatrics, McGill University Health Center
McGill University Health Centre/Research Institute of the McGill University Health Centre