Comparative Effect of Desogestrel and Combined Ethinyl Estradiol & Desogestrel on Cell Proliferation and Apoptosis of Ectopic Endometrial Tissues in Endometriosis : A Randomized Controlled Study
Not Applicable
Completed
- Conditions
- Patient with endometriotic cyst at least 3 cm in diameterEndometriosis
- Registration Number
- TCTR20140702001
- Lead Sponsor
- Faculty of Medicine, Ramathibodi hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 45
Inclusion Criteria
1 healthy women age 18 40 yrs
2 diagnose as endometrioma with more than 3 cm in
3 No history of hormonal usage within 3 months or no treatment of depot medroxyprogesterone acetate DMPA or GnRH agonist past 9 months
4 no contraindication for Ethinyl estradiol and Desogestrel
Exclusion Criteria
1)subjects with underlying disease which is not appropiate for taking combine pill, Ethinyl estradiol and Desgestrel
2)Contraindicate to Ethinyl estradiol ���Desgestrel
3)cannot tolerate to OC
4)deny to be recruited in the study
5)pathological report not endometriosis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method cell proliferation by Ki IHC, 1 month positive stained cells/100 cells,apoptosis by TUNEL assay 1 month positive stained cells/100 cells,antiapoptosis marker BCl2 1 month postive stained cells/100 cells
- Secondary Outcome Measures
Name Time Method Immunohistochemistry for macrophage (CD68) 1 month cell number of positive stained CD68 ,Immunohistochemistry for NK cells (CD57) 1 month cell number of positive stained CD57