The effect of minocycline on the post myocardial infarction left ventricular function in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary interventio
- Conditions
- Acute myocardial infarction.myocardial infarction specified as acute or with a stated duration of 4 weeks (28 days) or less from onset
- Registration Number
- IRCT201411188698N15
- Lead Sponsor
- Tehran Heart Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- All
- Target Recruitment
- 90
inclusion criteria:
1- Diagnosis of STEMI (chest pain>30 minutes and <12 hr, ST segment elevation in electrocardiogram>1 mm in at least 2 consecutive leads)
2- No history of heart failure
3- Giving consent to enter the study
4- Age>20 and <65 years
5- Successful PCI
exclusion criteria:
1- History of myocardial infarction
2- History of cardiac surgery (either CABG or valvular surgery)
3- History of electrophysiological interventions (ablation or device implantation)
4- Presence of cardiogenic shock at the time of admission
5- Chronic diseases with poor survival (malignancy, etc.)
6- Cardiomyopathy or hereditary muscular diseases
7- Chronic renal or hepatic insufficiency
8- new onset left bundle branch block in ECG
9- candidate for antithrombolytic therapy
10- Moderate to severe mitral regurgitation
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eft ventricular function. Timepoint: Baseline (within 48 hours from PCI) and 6 months later. Method of measurement: Echocardiography.
- Secondary Outcome Measures
Name Time Method Diastolic function. Timepoint: Baseline (within 48 hours from PCI) and 6 months later. Method of measurement: Echocardiography.;Tissue doppler indices. Timepoint: Baseline (within 48 hours from PCI) and 6 months later. Method of measurement: Color Doppler Echocardiography.