The effect of colchicine on reducing myocardial injury

Phase 3

Conditions: Coronary artery disease with angina pectoris.
Atherosclerotic heart disease of native coronary artery with angina pectoris
I25.11

Registration Number: IRCT20231015059731N1

Lead Sponsor: Khoram-Abad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 210

Inclusion Criteria

Suffering from stable and unstable angina pectoris and myocardial infarction without ST segment elevation diagnosed by a cardiologist and a candidate for coronary angiography
Not taking colchicine due to other diseases such as gout
Not having a history of myelodysplasia
Not taking corticosteroids or non-steroidal anti-inflammatory drugs except aspirin for 3 days before
Absence of malignancy or active infection

Exclusion Criteria

Being allergic to colchicine
Not being a candidate for angioplasty after angiography
Glomerular filtration below 30 ml/min

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Troponin. Timepoint: Troponin measurement is done 12 to 24 hours before the angioplasty procedure and also 24 hours after the procedure. Method of measurement: The level of troponin will be measured 12 to 24 hours before the procedure, exactly before receiving the first dose of the drug or placebo, and also 24 hours after the procedure by the laboratory technician with the HUBI TNI troponin quantitative kit.

Secondary Outcome Measures