SPECTA: Screening Cancer Patients for Efficient Clinical Trial Access

Recruiting

• Conditions: All Tumor Types
• Interventions: Genetic: RP-1843 Arcagen; Genetic: RP-1828 IMMUcan; Genetic: RP-1920 BioRadon; Genetic: RP-1759 AYA/TYA

• Registration Number: NCT02834884
• Lead Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Brief Summary

SPECTA is a quality assured platform for collecting clinicopathologically annotated biological material, imaging data, operative images, environmental assessment, questionnaires as well as patient-reported outcomes from cancer patients to support biospecimen-based translational research and clinical cancer research, including biomarker discovery to improve the understanding of tumor biology and cancer patients care.

Detailed Description

Patients are recruited in the platform for the research purpose of 4 downstream projects. For more information, please have a look at the "Groups and cohorts" section.

Study Timeline

• Study First Submitted: 2016-07-13
• Study First Submitted QC: 2016-07-13
• Study First Posted: 2016-07-15
• Study Start: 2017-05-03
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-29
• Last Update Posted: 2025-05-01
• Primary Completion: 2026-03
• Study Completion: 2026-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 4975

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
RP-1843 Arcagen (CLOSED for recruitment since November 2022)	RP-1843 Arcagen	This is a collaborative project between EORTC and EURACAN to perform molecular characterisation of rare cancers patients, using Foundation Medicine tests. The goal of this project is to get a better understanding of the genomic landscape of rare cancers and potentially help define possibilities for targeted treatments/clinical trials for this population. Tumor types: all 10 EURACAN domains
RP-1828 IMMUcan	RP-1828 IMMUcan	The goal is to generate broad molecular and cellular profiling data of the tumour and its microenvironment from cancer patients integrated with clinical data, to understand how the immune system and tumours interact, and the impact of current therapeutic interventions. Tumor types: Thorax, Head and Neck, Breast, Gastrointestinal, Genito Urinary
RP-1920 BioRadon	RP-1920 BioRadon	The primary objective is to assess the correlation between the molecular profiles of NSCLC patients and indoor radon concentration, measured with an alpha-particle detector (a standardized and validated way of measuring indoor radon). Tumor type: Thorax
RP-1759 AYA/TYA (CLOSED for recruitment since December 2021)	RP-1759 AYA/TYA	The pilot study will be focusing on young adults (12 to 29 years old) with rare cancer to understand better the biology of the tumor in this specific population, and compare it to children and adults with similar disease, as well as to improve the inclusion of young adults into clinical trials. Tumor type: CNS

Primary Outcome Measures

Name	Time	Method
To establish a quality assured platform to improve the understanding of tumor biology and cancer patients care	5 years	material (including imaging data) as well as patient-reported outcomes from patients with cancer diagnosis to support biospecimen-based translational research and biomarker discovery to improve the understanding of tumor biology and cancer patients care.

Secondary Outcome Measures

Name	Time	Method
To perform biospecimen and data based high quality research aiming to better understand the biology of cancer, and/or how it is currently managed and/or how to better diagnose and treat it in the future;	5 years
To investigate the effect of cancer treatment on the tumor, microenvironment and patients globally;	5 years
To collect large series of homogeneous clinical data to analyse the disease course and treatment performed;	5 years
To investigate the molecular pathways related to the development of specific tumors from a biological point of view;	5 years
To investigate the prevalence and validate the prognostic or predictive value of novel biomarkers in cancers;	5 years
To perform biospecimen and data based high quality research aiming to facilitate the discovery of new test for tumor biomarkers or facilitate the establishment of validated tests for tumor biomarkers;	5 years
To identify patients with molecular alterations in their tumor that can be matched to biomarker-driven clinical trials, to facilitate enrollment of cancer patients in biomarker-driven clinical trials.	5 years

Trial Locations

Locations (134)

CHU de Bordeaux - Groupe Hospitalier Saint-Andre - Hopital Saint-Andre; 🇫🇷 Bordeaux, France

University Hospital Motol; 🇨🇿 Prague, Czechia

Centre Eugene Marquis; 🇫🇷 Rennes, France

Medical University Vienna - General Hospital AKH; 🇦🇹 Vienna, Austria

Onze Lieve Vrouw Ziekenhuis; 🇧🇪 Aalst, Belgium

ZAS Middelheim; 🇧🇪 Antwerp, Belgium

Hopitaux Universitaires - Institut Jules Bordet; 🇧🇪 Brussels, Belgium

Universitair Ziekenhuis Brussel; 🇧🇪 Brussels, Belgium

Cliniques Universitaires Saint-Luc; 🇧🇪 Brussels, Belgium

Universitair Ziekenhuis Gent; 🇧🇪 Gent, Belgium

Pole Hospitalier Jolimont - Hopital Jolimont; 🇧🇪 Haine-Saint-Paul, Belgium

U.Z. Leuven - Campus Gasthuisberg; 🇧🇪 Leuven, Belgium

C.H.U. Sart-Tilman; 🇧🇪 Liège, Belgium

Centre Hospitalier Regional De La Citadelle; 🇧🇪 Liège, Belgium

CHU Site Sainte-Elisabeth-UCL Namur; 🇧🇪 Namur, Belgium

AZ Turnhout - Campus Sint Elisabeth; 🇧🇪 Turnhout, Belgium

CHU Mont Godinne - UCL Namur; 🇧🇪 Yvoir, Belgium

University Hospital Centre Zagreb; 🇭🇷 Zagreb, Croatia

Bank Of Cyprus Oncology Centre; 🇨🇾 Stróvolos, Cyprus

North Estonia Medical Centre - Mustamäe unit; 🇪🇪 Tallinn, Estonia

Centre Hospitalier Avignon; 🇫🇷 Avignon, France

CHRU de Besancon - Hopital Jean Minjoz; 🇫🇷 Besancon, France

Centre de Radiotherapie Pierre Curie; 🇫🇷 Beuvry, France

Institut Bergonie; 🇫🇷 Bordeaux, France

Centre Hospitalier - Boulogne Sur Mer; 🇫🇷 Boulogne-sur-Mer, France

CHU de Lyon - Hopital Louis Pradel; 🇫🇷 Bron, France

CHU Lyon - Hopital neurologique Pierre Wertheimer; 🇫🇷 Bron, France

Centre Francois Baclesse; 🇫🇷 Caen, France

Centre Hopitalier Intercommunal De Creteil; 🇫🇷 Creteil, France

Centre Georges-Francois-Leclerc; 🇫🇷 Dijon, France

CHU de Grenoble - La Tronche - Hôpital A. Michallon; 🇫🇷 Grenoble, France

Centre Hospitalier Departemental Vendee; 🇫🇷 La Roche Sur Yon, France

Centre Oscar Lambret; 🇫🇷 Lille, France

CHRU de Lille; 🇫🇷 Lille, France

CHU de Lyon - Hopital Edouard Herriot; 🇫🇷 Lyon, France

Centre Léon Berard; 🇫🇷 Lyon, France

CHU de Lyon - Hopital Lyon Sud; 🇫🇷 Lyon, France

Assistance Publique - Hopitaux de Marseille - Hopital Nord; 🇫🇷 Marseille, France

Centre Hospitalier D'Annecy Genevois; 🇫🇷 Metz-Tessy, France

CHU Montpellier-Hopital Arnaud De Villeneuve; 🇫🇷 Montpellier, France

Institut du Cancer de Montpellier; 🇫🇷 Montpellier, France

Centre Hospitalier Des Pays De Morlaix; 🇫🇷 Morlaix, France

Centre d'Oncologie de Gentilly; 🇫🇷 Nancy, France

CHU de Nice - Hopital De L'Archet; 🇫🇷 Nice, France

Assitance Publique - Hopitaux de Paris - Hopital Saint-Louis; 🇫🇷 Paris, France

Assistance Publique - Hopitaux de Paris - Hopital Saint Antoine; 🇫🇷 Paris, France

Assistance Publique - Hopitaux de Paris - La Pitie Salpetriere; 🇫🇷 Paris, France

Institut Curie- Hopital de Paris; 🇫🇷 Paris, France

Groupe Hospitalier Paris Saint-Joseph - Hopital Saint Joseph; 🇫🇷 Paris, France

Clinique Mutualiste de l'Estuaire - Centre d'oncologie; 🇫🇷 Saint Nazaire, France

Institut de Cancerologie de l'Ouest (ICO) - Centre Rene Gauducheau; 🇫🇷 Saint-Herblain, France

Institut de Cancerologie de la Loire Lucien Neuwirth; 🇫🇷 Saint-Priest-en-Jarez, France

Institut de Cancerologie Strasbourg Europe (formar Paul Strauss); 🇫🇷 Strasbourg, France

CHU Toulouse - Hopital Larrey; 🇫🇷 Toulouse, France

Gustave Roussy; 🇫🇷 Villejuif, France

Charite - Universitaetsmedizin Berlin - Campus Virchow-Klinikum; 🇩🇪 Berlin, Germany

Universitaetsklinikum Carl Gustav Carus; 🇩🇪 Dresden, Germany

Universitaetsklinikum Greifswald der Ernst Morizt Arndt Univ. Greifswald AoR; 🇩🇪 Greifswald, Germany

Universitaetsklinikum Jena; 🇩🇪 Jena, Germany

Onkologie UnterEms, Leer-Papenburg-Emden; 🇩🇪 Leer, Germany

NIMTS - Veterans Administration Hospital; 🇬🇷 Athens, Greece

Athens University - Attikon University General Hospital; 🇬🇷 Athens, Greece

Hygeia Hospital; 🇬🇷 Athens, Greece

Ioannina University Hospital; 🇬🇷 Ioánnina, Greece

Ospedale Civile Santi Antonio e Biagio e Cesare Arrigo; 🇮🇹 Alessandria, Italy

Alma Mater Studiorium Universita di Bologna - Loc. Ospedala Sant'Orsolo; 🇮🇹 Bologna, Italy

Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia; 🇮🇹 Brescia, Italy

Azienda Istituti Ospitalieri di Cremona; 🇮🇹 Cremona, Italy

IRCCS Azienda Ospedaliera Universitaria San Martino "IST" Istituto Nazionale per la Ricerca sul Cancro; 🇮🇹 Genova, Italy

Azienda Unita Locale Socio-Sanitaria N. 9-Mater Salutis Hospital; 🇮🇹 Legnago, Italy

IRCCS - Istituto Neurologico Carlo Besta; 🇮🇹 Milano, Italy

Azienda Sanitaria Locale Napoli 1 Centro; 🇮🇹 Napoli, Italy

Universita Di Torino - Ospedale S. Luigi Gonzaga; 🇮🇹 Orbassano, Italy

IRCCS - Istituto Oncologico Veneto; 🇮🇹 Padova, Italy

Istituti Clinici Scientifici Maugeri; 🇮🇹 Pavia, Italy

Regina Elena National Cancer Center; 🇮🇹 Roma, Italy

Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale Molinette; 🇮🇹 Torino, Italy

Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale San Giovanni - Dipartimento Neuroscienze; 🇮🇹 Torino, Italy

Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale Sant'Anna; 🇮🇹 Torino, Italy

Lithuanian Oncology Center-Nat. Cancer Inst; 🇱🇹 Vilnius, Lithuania

The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis; 🇳🇱 Amsterdam, Netherlands

Amsterdam UMC - Locatie AMC; 🇳🇱 Amsterdam, Netherlands

University Medical Center Groningen; 🇳🇱 Groningen, Netherlands

Academisch Ziekenhuis Maastricht; 🇳🇱 Maastricht, Netherlands

Radboud University Medical Center Nijmegen; 🇳🇱 Nijmegen, Netherlands

Medical University Of Gdansk; 🇵🇱 Gdansk, Poland

Maria S. Curie Memorial Institute-Gliwice Branch; 🇵🇱 Gliwice, Poland

The Great Poland Cancer Centre; 🇵🇱 Poznan, Poland

Maria Sklodowska-Curie Memorial Cancer Centre; 🇵🇱 Warsaw, Poland

Instituto Portugues De Oncologia - Centro De Coimbra; 🇵🇹 Coimbra, Portugal

Instituto Portugues de Oncologia de Lisboa Francisco Gentil - EPE; 🇵🇹 Lisboa, Portugal

Hospital CUF Tejo; 🇵🇹 Lisboa, Portugal

Centro Hospitalar de Lisboa Ocidental- San Francisco Xavier Hospital; 🇵🇹 Lisboa, Portugal

Hospital CUF Descobertas; 🇵🇹 Lisboa, Portugal

Centro Hospitalar do Porto- Hospital de Santo Antonio; 🇵🇹 Porto, Portugal

Instituto Portugues de Oncologia do Porto; 🇵🇹 Porto, Portugal

Unidade Local de Saúde Gaia e Espinho; 🇵🇹 Vila Nova De Gaia, Portugal

Medisprof Cancer Center srl; 🇷🇴 Cluj, Cluj Napoca, Romania

University Clinic Centre Serbia - Pulmonology clinic; 🇷🇸 Belgrade, Serbia

University Clinical Center of Serbia - Clinic for ENT and MFH; 🇷🇸 Belgrade, Serbia

University Clinic Golnik; 🇸🇮 Golnik, Slovenia

University Medical Center Maribor; 🇸🇮 Maribor, Slovenia

ICO L'Hospitalet - Hospital Duran i Reynals (Institut Catala D'Oncologia); 🇪🇸 L' Hospitalet De Llobregat, Barcelona, Spain

Vall d'Hebron Institut d'Oncologia; 🇪🇸 Barcelona, Spain

Hospital Clinic Universitari de Barcelona; 🇪🇸 Barcelona, Spain

Hospital De La Santa Creu I Sant Pau; 🇪🇸 Barcelona, Spain

Hospital General Universitario De Elche; 🇪🇸 Elche, Spain

ICO Girona - Hospital Doctor Josep Trueta (Institut Catala D'Oncologia); 🇪🇸 Girona, Spain

ICO L'Hospitalet- Hospital Universitari de Bellvitge; 🇪🇸 L'Hospitalet De Llobregat, Spain

Hospital Infantil Universitario Nino Jesus; 🇪🇸 Madrid, Spain

Hospital Universitario Infanta Leonor; 🇪🇸 Madrid, Spain

Hospital Universitario Ramon y Cajal; 🇪🇸 Madrid, Spain

Hospital Universitario San Carlos; 🇪🇸 Madrid, Spain

Hospital Universitario 12 de Octubre; 🇪🇸 Madrid, Spain

Hospital Universitario QuironSalud; 🇪🇸 Madrid, Spain

Hospital Universitario Virgen De La Victoria; 🇪🇸 Malaga, Spain

Hospital Clinico Universitario De Valencia; 🇪🇸 Valencia, Spain

Hospital Clinico Universitario De Valladolid; 🇪🇸 Valladolid, Spain

Hospital Clinico Universitaro De Valladolid; 🇪🇸 Valladolid, Spain

Hirslanden Klinik-Tumor Zentrum Aarau; 🇨🇭 Aarau, Switzerland

Kantonsspital St Gallen; 🇨🇭 Saint Gallen, Switzerland

UniversitaetsSpital Zurich; 🇨🇭 Zurich, Switzerland

Betsi Cadwaladr University Health Board - Glan Clwyd District General Hospital; 🇬🇧 Bodelwyddan, Denbighshire, United Kingdom

University Hospitals Birmingham NHS Foundation Trust (UHB) - UHB-Queen Elisabeth Medical Centre; 🇬🇧 Birmingham, United Kingdom

Royal Orthopaedics Hospital, NHS Trust; 🇬🇧 Birmingham, United Kingdom

Cambridge University Hospital NHS - Addenbrookes Hospital; 🇬🇧 Cambridge, United Kingdom

Velindre NHS Trust - Velindre Cancer Centre; 🇬🇧 Cardiff, United Kingdom

University Hospitals Coventry and Warwickshire NHS Trust - University Hospital; 🇬🇧 Coventry, United Kingdom

NHS Lothian - Western General Hospital; 🇬🇧 Edinburgh, United Kingdom

NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital; 🇬🇧 Glasgow, United Kingdom

Hereford County Hospital; 🇬🇧 Hereford, United Kingdom

Leeds Teaching Hospitals NHS Trust - St. James's University Hospital; 🇬🇧 Leeds, United Kingdom

Royal Free Hospital; 🇬🇧 London, United Kingdom

The Christie NHS Foundation Trust; 🇬🇧 Manchester, United Kingdom