The association between the 5-LO pathway & abdominal aortic aneurysms.
Recruiting
- Conditions
- patients with a small abdominal aneurysm of the aorta.
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
presence of asymptomatic, small AAA, older than 20 years, male or female
Exclusion Criteria
1. A clinical condition which is actual and may interfere with the endpoints of the study (e.g. malignancy, infection/sepsis, chronic inflammatory disease ).
2. The use of drugs with anti-inflammatory properties including prostaglandin synthetase inhibitors, which have been shown to reduce the inflammatory response
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. The relation between LT levels (in stimulated neutrophils and urine) and annual rate of expansion of small AAAs.<br /><br>2. Comparison of LT levels between subjects with AAA and normal controls. <br /><br>3. The association between at-risk gene variant genes involved in 5-LO pathway and AAA growth rate. (4) To assess the presence of neutrophils and 5-LO products in AAA specimens<br /><br><br>
- Secondary Outcome Measures
Name Time Method The relation between other inflammatory markers. (e.g. MMP9, hsCRP, MIP-1a, RANTES, MCP-1, CD-40L) and rates of expansion of small AAAs