The association between the 5-LipOxygenase pathway and abdominal aortic aneurysms

Not Applicable

Completed

• Conditions: Abdominal aneurysm of the aorta; Circulatory System; Circulatory diseases

• Registration Number: ISRCTN03932642
• Lead Sponsor: Academic Medical Center (AMC) (The Netherlands)

Brief Summary

2012 genetic analysis results in https://pubmed.ncbi.nlm.nih.gov/22129473/ (added 14/01/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-12-28
• Study Completion: 2009-11-01
• Last Update Posted: 25 January 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

1. Presence of asymptomatic, small AAA
2. Older than 20 years
3. Male or female

Exclusion Criteria

1. A clinical condition which is actual and may interfere with the endpoints of the study (e.g. malignancy, infection/sepsis, chronic inflammatory disease )
2. The use of drugs with anti-inflammatory properties including prostaglandin synthetase inhibitors, which have been shown to reduce the inflammatory response
3. The use of immunosuppressants, including glucocorticoids, e.g., cyclosporine
4. Ruptured/symptomatic AAAs

Study & Design

• Study Type: Interventional
• Study Design: Not specified