NCT02171091终止不适用
Impact of the Endotracheal Tube on Airway Inflammation: Prospective Analysis in Intubated ICU Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Neutrophil changes
研究概览
简要总结
The purpose of this research study is to determine how cell changes during endotracheal intubation and artificial lung ventilation affect lung inflammation.
Patients will undergo placement of an endotracheal tube (ETT) as standard of care. Tracheal (windpipe) lavage will be obtained each day for up to 72 hours. Lung samples or fiberoptic (lung) samples will be collected at the same time intervals when possible and if they are done as standard of care.
Blood samples will be obtained simultaneous with the collection of the trachael (windpipe) specimens.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Neutrophil changes
时间窗: 72 hours
Identifying indicators of neutrophil inflammatory changes that occur during 72 hours of tracheal injury secondary to endotracheal intubation.
次要结局
- analyze neutrophil activation(72 hours)
- correlate tracheal and lung neutrophil activation(72 hours)
- determine the impact of airway (tracheal, lung) inflammation(72 hours)
研究者
研究点 (1)
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