Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis

Not Applicable

Active, not recruiting

Brief Summary: This study will evaluate whether use of antidepressants can reduce gingival inflammation in patients with periodontal (gum) disease.

Detailed Description: The primary purpose of this study is to evaluate whether use of antidepressants can reduce gingival inflammation in patients with periodontal (gum) disease. This study will also investigate the link between oral and systemic inflammation in patients diagnosed with depression and periodontal disease. Researcher will collect gingival crevicular fluid, plaque, tissue and blood serum samples to evaluate the link between these two diseases. The collection of gingival crevicular fluid, plaque and blood serum is relatively non-invasive, elicits minimal discomfort and does not require use of any anesthesia. The soft tissue sample will be collected as part of an otherwise planned periodontal surgical procedure under local anesthesia. In periodontal therapy (surgical procedures i.e. gum surgery, tooth extraction and or dental implant surgery) there is enough availability of remnant tissue for the collection of samples, which is otherwise discarded.

Recruitment & Eligibility

Inclusion Criteria

At least 18 years old
Must be a patient of the UAB Dental School
Able to read and understand informed consent document
Good general health as evidenced by medical history
Minimum of 18 teeth, excluding third molars
Having moderate to severe periodontal disease according to AAP definition (teeth ≥5 mm PD and ≥3 mm CAL)
Having >30 percent bleeding sites upon probing
Patients taking depression medication with chronic periodontitis
Patients without depression with chronic periodontitis
Patients who have not had a dental cleaning in the past 3 months prior to procedure
Patients scheduled for surgical procedures (i.e. gum surgery, tooth extraction, or dental implants)

Exclusion Criteria

Non-English speaking
Less than 18 years old
Smokers/tobacco users (>10 cigarettes/day)
Any dental condition that requires immediate treatment, such as emergency care
Chronic use (≥3 times/week) of anti-inflammatory medications (e.g., non-steroidal anti-inflammatory drugs, steroids). Low-dose aspirin (less than 325 mg daily)
Immunocompromised subjects
Any medical history or any concomitant medication that might affect the assessment of the study treatment or periodontal tissues, such as uncontrolled diabetes, nifedipine, phenytoin (Dilantin), subjects with arthritis and morbidly obese (BMI ≥ 40)

Arm && Interventions

Group	Intervention	Description
Chronic Periodontitis and Depression Medications	Periodontal Surgery	Patients with clinically diagnosed depression taking (SSRIs, NDRIs, SNRIs, tricyclic antidepressants) and with chronic periodontitis
Chronic Periodontitis without Depression Medications	Periodontal Surgery	Patients with clinically diagnosed depression not taking any antidepressants (SSRIs NDRIs, SNRIs and Tricyclic antidepressants) and with chronic periodontitis
Chronic Periodontitis	Periodontal Surgery	Patients without depression, not taking any antidepressants and with chronic periodontitis

Primary Outcome Measures

Name	Time	Method
Gingival crevicular fluid (GCF)	baseline to 1 week	Measuring oral inflammatory markers in Gingival crevicular fluid (GCF) in patient with chronic periodontitis.

Secondary Outcome Measures

Name	Time	Method
Plaque	baseline to 1 week	Analyze the type of bacteria that is present in patient with chronic periodontitis.

Locations (1): Unversity of Alabama at Birmingham, School of Dentistry
🇺🇸
Birmingham, Alabama, United States

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