Inflammatory Biomarkers in Saliva at Depression
- Conditions
- Inflammatory ResponseGingivitisDepressionInflammation
- Registration Number
- NCT06427902
- Lead Sponsor
- Medipol University
- Brief Summary
The goal of this observational study is to evaluate the inflammatory saliva biomarkers in depression and gingivitis.
The main question will be ; Will there be an increase at salivary biomarkers with depression patients and is it associated with gingivitis?
- Detailed Description
Background: The neuroimmune regulation disorder in depression patients causes the progression of inflammatory periodontal disease. The present study was to evaluate the periodontal health status and the levels of Triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1) and interleukin-1 beta (IL-1β) in individuals diagnosed with depression and to compare these findings with those of systemically healthy individuals.
Methods: Forty-two depression patients were classified in two groups: depression with gingivitis (DG) and depression with periodontally healthy (DPH) patients. Additionally, 23 systemically and periodontally healthy (SPH) individuals were enrolled to the study. Periodontal parameters were recorded. Saliva samples were collected and salivary levels of TREM-1, PGLYRP1, IL-1β were measured using Enzyme-linked Immunosorbent Assay (ELISA) kits.
depression regardless of periodontal status.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 65
- Patients who were moderate in severity according to the test result, who had not started drug therapy yet and who had not received antidepressant medication in the last 12 months
Patients with
- psychotic disorders
- autism spectrum disorders
- other anxiety disorders
- bipolar disorder
- mental any organic mental disorder and
- smokers, substance users
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Salivary PGLYRP1 06-09 2019 Both, soluble and membrane-bound PGLYRP1 are detected by the PGLYRP1 ELISA.
SalivaryTREM-1 06-09 2019 Both, soluble and membrane-bound TREM-1, are detected by the TREM-1 ELISA.
Salivary IL-1β 06-09 2019 Both, soluble and membrane-bound IL-1β detected by the IL-1β ELISA.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Duygu Ilhan
🇹🇷Istanbul, Select State, Turkey
Duygu Ilhan🇹🇷Istanbul, Select State, Turkey