Association Between Intraoperative Heart Rate and Postoperative 30-day Mortality in Non-cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 139,149
- 试验地点
- 1
- 主要终点
- All-cause mortality within 30 days after non-cardiac surgery
研究概览
简要总结
This retrospective observational study investigates the association between intraoperative heart rate and 30-day postoperative mortality among patients undergoing non-cardiac surgery. The findings suggest that heart rate abnormalities during surgery may significantly affect short-term postoperative outcomes.
详细描述
This is a retrospective cohort study conducted to evaluate the clinical impact of intraoperative heart rate on postoperative 30-day mortality in patients undergoing non-cardiac surgery. Patient data were extracted from a large institutional electronic medical record database, including demographic variables, comorbidities, anesthesia records, and perioperative outcomes.
Heart rate was continuously recorded at 1-minute or 5-minute intervals during the surgery. Various heart rate parameters-such as minimum, maximum, average, and time-weighted average-were analyzed, and threshold-based metrics (e.g., minutes spent below or above defined thresholds) were computed using a piecewise cubic Hermite interpolating polynomial (PCHIP) method to smooth minute-by-minute fluctuations.
The primary outcome was all-cause mortality within 30 days after surgery. Multivariable logistic regression and sensitivity analyses were performed to adjust for potential confounders. The study aimed to provide clinical insight into the prognostic value of intraoperative heart rate dynamics and to identify modifiable intraoperative risk factors for mortality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent non-cardiac surgery at our medical center between March 2019 and February 2023
- •Age ≥ 18 years
- •Availability of complete laboratory data and perioperative vital signs
- •Only the first surgery performed after hospital admission was included for patients with multiple
排除标准
- •Cardiac-related surgical procedures
- •Pregnancy at the time of surgery
- •Age < 18 years
- •Surgeries lasting less than 30 minutes
- •Cadaveric procedures
- •Missing or incomplete laboratory values or vital sign data
结局指标
主要结局
All-cause mortality within 30 days after non-cardiac surgery
时间窗: 30 days after the date of surgery
The primary outcome is defined as death from any cause occurring within 30 days after the date of surgery. Mortality data were collected from institutional electronic medical records and verified through discharge and follow-up records. The association between intraoperative heart rate metrics and postoperative mortality was retrospectively analyzed.
次要结局
未报告次要终点
研究者
Sung-Hoon Kim
Associate Professor
Asan Medical Center