Project PROTECT: Protecting Nursing Homes From Infections and Hospitalization
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Enrollment
- 13,952
- Locations
- 28
- Primary Endpoint
- Hospital Transfers Due to Infection
Study Overview
Brief Summary
This is a cluster-randomized trial of nursing homes to assess whether decolonization with routine chlorhexidine bathing and periodic use of nasal antiseptics can reduce hospitalizations associated with infections, antibiotic utilization, and multi-drug resistant organism (MDRO) prevalence. The comparator arm will be routine bathing care.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Decolonization
Nursing homes assigned to this arm will perform decolonization using topical antiseptic products.
Intervention: Chlorhexidine gluconate (CHG) (Drug)
Decolonization
Nursing homes assigned to this arm will perform decolonization using topical antiseptic products.
Intervention: Iodophor (10% povidone-iodine) (Drug)
Outcomes
Primary Outcomes
Hospital Transfers Due to Infection
Time Frame: 18 months
Probability that a transfer to a hospital is due to an infection
Secondary Outcomes
- All Hospital Transfers(18 months)
Investigators
Susan Huang
Professor and Medical Director of Epidemiology and Infection Prevention
University of California, Irvine