相关临床试验
476
48 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1965
进行中（未招募）
26
5.5%
Approved For Marketing
1
0.2%
已完成
242
50.8%
Enrolling By Invitation
5
1.1%
尚未招募
17
3.6%
招募中
78
16.4%
暂停
2
0.4%
终止
31
6.5%
Unknown
8
1.7%
撤回
66
13.9%
暂无批准数据
- PerZeption Inc. has received a Phase I SBIR grant from the National Eye Institute to develop an achromatic and chromatic photostress recovery test for age-related macular degeneration. - The Boston-based company will run the study with researchers at the Brunson Center for Translational Vision Research at the University of California, Irvine. - The funded work aims to characterize the full post-light-exposure recovery curve on PerZeption's Angular Indication Measurement platform rather than a single recovery time point. - Phase I NEI SBIR awards carry up to $323,090 in total costs, and the project is intended to generate feasibility data supporting a regulatory pathway.
- Researchers at UC Irvine created human neocortical organoids steered toward either front or back cortical identity, reproducing molecular characteristics of prenatal human cortex across more than 200,000 cells. - The new model revealed that fragile X syndrome flattens the normal front-to-back difference in SOX4 and SOX11 protein levels, a pattern also reported in donated brain tissue from people with autism. - The approach gives lab-grown cortical tissue a reproducible "biological compass," enabling researchers to study not only what changes in neurodevelopmental disorders but also where those changes emerge. - The platform contributes to human tissue-based research models that complement animal studies and could help probe disease mechanisms and potential therapeutic strategies.
- A global survey of 282 oncology providers found that more than 80% cite lack of knowledge as a key barrier to recommending integrative oncology therapies such as yoga, acupuncture, and mindfulness training. - Financial obstacles including lack of insurance coverage and high out-of-pocket costs were identified by roughly 80% of respondents as preventing patient access to complementary cancer care. - European providers were more than twice as likely as North American counterparts to report knowledge gaps as a barrier (OR = 2.22, 95% CI = 1.05–4.67, P = .036). - Researchers propose continuing education, mentorship programs, and EHR-integrated resource libraries as actionable solutions to close the knowledge gap.
- A 20-year observational study of nearly 67,000 postmenopausal women found that high adherence to the Planetary Health Diet was associated with a 28% lower risk of cardiovascular disease. - Even moderate dietary adherence showed statistically significant cardiovascular risk reductions, with each 10-point increase in diet score linked to further benefit. - The diet emphasizes fruits, vegetables, whole grains, legumes, nuts, and unsaturated fats while limiting red and processed meats, added sugars, and saturated fats. - Researchers caution that as an observational study, causality cannot be established, and full peer-reviewed publication is pending.
- ADLM 2026 convenes July 26–30 in Anaheim, California, bringing together nearly 17,000 global leaders in clinical laboratory medicine. - Dr. David M. Nathan will open the meeting reflecting on five decades of diabetes research, including his pioneering work establishing hemoglobin A1c as the gold-standard test and the role of GLP-1 in glucose regulation. - Dr. Elizabeth Head will present her 25-year investigation into the Alzheimer's–Down syndrome connection, exploring intervention targets that may inform precision medicine for the broader aging population. - Dr. Arun Wiita will close the conference with mass spectrometry-based discovery of novel cancer biomarkers on blood cancer cell membranes, with potential to yield new immune-based therapies.
- Cal State Fullerton researchers began collecting environmental samples from three Ladera Ranch parks after at least six children were diagnosed with Ewing sarcoma since 2013. - Surrounding areas have recorded 9 to 12 cases of Ewing and synovial sarcoma with six deaths, though a 2024 county review found no unusual pattern. - Residents are pressing the homeowners association to stop pesticide spraying, while a law firm investigates possible environmental exposures. - State and local agencies, including the California Cancer Registry, are conducting an updated review of cancer data, with findings expected in coming weeks.
- A UC Irvine-led study published in Nature Communications found that Greenland sharks, the longest-living vertebrates, show no signs of retinal degeneration despite living up to 400 years. - Researchers identified a DNA repair mechanism that may protect the shark retina from age-related decline, with rhodopsin remaining active and tuned to blue light for low-light vision. - The findings challenge the long-held assumption that Greenland sharks are functionally blind due to eye parasites and their dark Arctic habitat. - The work may eventually inform research on age-related human eye diseases such as macular degeneration and glaucoma.
- A UC Irvine and McLean Hospital study published in Nature Mental Health found that using biological and behavioral biomarkers to guide antidepressant selection improved response rates by nearly 67% compared to patients without favorable biomarker profiles. - Response rates reached 71.4% among patients with positive biomarkers for both sertraline and bupropion, versus 42.8% for those with no positive biomarkers. - The research represents one of the first efforts to test biomarker-guided antidepressant treatment selection in major depressive disorder, though the small sample size (fewer than 50 patients) limits immediate clinical applicability. - Researchers caution that costly functional MRI scans used in the study are not yet practical for routine clinical settings, but the findings lay groundwork for larger precision psychiatry trials.
- A prospective biomarker-guided trial found that patients with favorable biological markers for both sertraline and bupropion achieved a 71.4% response rate versus 42.9% for those with no positive markers, a nearly 67% improvement. - The study used functional MRI brain connectivity, cognitive reward sensitivity, and clinical profiles to predict treatment outcomes in major depressive disorder, though the primary matched-vs-unmatched drug comparison did not reach statistical significance. - Researchers caution that the small sample size (fewer than 50 patients) and high cost of fMRI scans mean the approach is not yet ready for routine clinical deployment. - The findings provide proof of concept that depression is biologically heterogeneous and that objective biomarkers may eventually guide personalized antidepressant selection, fast-tracking non-responders to alternative therapies.
- A growing body of research highlights persistent sex-based disparities in oncology clinical trial enrollment, with women often underrepresented relative to disease burden. - Sex differences in adverse event risk are documented, with female patients experiencing higher rates of severe toxicities from immunotherapy, targeted therapy, and chemotherapy. - Biological factors including sex hormone signaling, cytochrome P450 enzyme variation, and dimorphic immune responses may underlie differential treatment outcomes and toxicities. - Experts call for moving beyond simply increasing female enrollment toward achieving equity through sex- and gender-based analysis in trial design and interpretation.
