Evaluation of the effects of increasing amounts of protein in test meal on gastrointestinal hormone secretion, appetite and energy intake in lean and overweight subjects

Not Applicable

Completed

Conditions: obesity
Diet and Nutrition - Obesity
Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

Registration Number: ACTRN12610000315011

Lead Sponsor: A/Prof Christine Feinle-Bisset

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Male

Target Recruitment: 32

Inclusion Criteria

Healthy lean and overweight males, who do not exhibit any of the exclusion criteria detailed below

Exclusion Criteria

-significant gastrointestinal symptoms, disease or surgery
-use of medications which may affect gastrointestinal function, body weight or appetite
-gallbladder, pancreatic, cardiovascular or any respiratory diseases
-high performance athletes
-intake of alcohol of >20g/day
-smoking >10 cigarettes/ day
-lactose or any other food intolerances
-in lean subjects the degree of eating restraint, measured via the restraint component of the Three Factor Eating questionnare will be used as exclusion criteria (subjects with a resraint score >12 will be excluded)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Energy intake (measured in kJ, from food intake quantified using a buffet meal)[T= 210mins on each of the four study visits.]

Secondary Outcome Measures

Name	Time	Method
Plasma hormone levels (Cholecystokinin, Peptide YY)[T=-15, 0, 15, 30, 60, 90, 120, 150, 180, 210 on each study visit];Blood glucose levels (measured using a calibrated glucometer)[T=-15, 0, 15, 30, 60, 90, 120, 150, 180, 210 on each study visit];Appetite ratings; Measured using a validated visual analogue scale (VAS).[T=-15, 0, 15, 30, 60, 90, 120, 150, 180, 210 on each study visit];Macronutrient consumption (measured in kJ using quantified food intake at a buffet meal)[T=210mins on each study visit]