Platelet analysis in patients with haematological diseases with increased risk of thrombosis and bleeding

Completed

• Conditions: bleeding; thrombosis; 10018865; 10014523

• Registration Number: NL-OMON55308
• Lead Sponsor: Catharina-ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 102

Inclusion Criteria

Patients with hematological disease and drugs with increased bleeding or
thrombosis risk
For cases: with thrombosis or bleeding
For controls: without bleeding or thrombosis

Exclusion Criteria

- <18 year. - >1 platelet inhibiting drug

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Determinants<br /><br>- Extent of thrombus formation and platelet activation under flow<br /><br>- Cytosolic calcium activation in platelets<br /><br>- Platelet leukocyte complex formation<br /><br>- Platelet protein expression<br /><br>Outcome<br /><br>Bleeding or thrombosis</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Difference of platelet assays in cases vs. controls</p><br>