Study of genetic alterations in patients with Keratoconus using DNA sequencing technique dna
Not Applicable
- Conditions
- Keratoconus, mutation, geneC11.204.627
- Registration Number
- RBR-624vfv
- Lead Sponsor
- niversidade Federal de Goias
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Volunteers between 18-40 years of age with keratoconus; without keratoconus; no surgery or previous eye diseases; absence of systemic diseases; who accept sign the consent form and clarification
Exclusion Criteria
volunteers under the age of 18 years and above 40 years; who did not accept to sign the consent form and enlightenment; with diseases or previous eye surgery; systemic diseases
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method It`s hoped the polymorphism of the gene VSX1, mir-184, DOCK9 in patients with keratoconus and not the phenotype expression in control patients;Observe VSX1 gene polymorphism, mir-184 and DOCK9 by qPCR technique for identifying DNA mutant alleles
- Secondary Outcome Measures
Name Time Method It is expected that the polymorphism VSX1 genes, miR-184, DOCK9 is expressed in at least 5% of the population with keratoconus and is statistically significant compared to controls