Functional ICUS in Uganda and Their Survival Outcomes

• Conditions: Critical Illness

• Registration Number: NCT03511742
• Lead Sponsor: Makerere University

Brief Summary

Aim of the study is to describe the functional characteristics of Icus in Uganda and their @8-day patient characteristics it is a prospective cohort study .All Icus in Uganda will be included and their admitted patients followed upto 28 days in the ICU for mortality

Detailed Description

Intensive Care units are specialized units with expertise to provide organ support for the critically ill patients. There's a growing global burden of critical illness especially in the low-income coun-tries where critical care services are limited. Despite advances in critical care, the mortality in Uganda remains very high, with sepsis and trauma as the major contributors. There's paucity of literature regarding ICUs characteristics, disease burden and patient characteristics which could be contributing to the high mortality.

Objectives To describe the functional characteristics of the ICUs in Uganda. To determine the ICU mortality of critically ill patients in Uganda. To determine the risk factors of mortality of patients admitted in the ICU Methods A prospective cohort study will be carried out in all ICUs in Uganda. All new patients in the ICUs will be recruited into the study. Data will be collected onto two separate questionnaires, one for patient characteristics and the second for ICU functional characteristics. The patient's data will be collected within the first 24 hours and patients will be followed up for death\\discharge within 28 days in the ICU. The data will be collected from the patients' charts and entered into Epidata.

Study Timeline

• Study Start: 2018-01-08
• Status Verified: 2018-04
• Study First Submitted: 2018-04-10
• Study First Submitted QC: 2018-04-26
• Last Update Submitted: 2018-04-26
• Primary Completion: 2018-04-30
• Study Completion: 2018-04-30
• Study First Posted: 2018-04-30
• Last Update Posted: 2018-04-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 367

Inclusion Criteria

All new patients admitted to Uganda's Intensive Care Units ICUs in Uganda whose unit heads verbally consent to participate in the study.

Exclusion Criteria

Patients transferred in from another unit will not be re recruited. ICUs that don't consent to the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
functional characteristics of ICUs in Uganda	3 months	outcome measure will be descriptive, that is interms of ICU location(urban or rural), staffing (nurse to patient ratio), infrastructure(floor space cm2), monitoring equipment, services rendered(organ support), and the ICU operation models(closed versus open) will be assessed for association with patient outcome
28 day mortality	3 months	Total number of patients who died during the study period within 28 days over the total number recruited, and a survival analysis will be plowed on a Kaplan Meier

Secondary Outcome Measures

Name	Time	Method
factors associated with mortality	3 months	Age ( years), sex, indication for admission, length of ICU stay(days), comorbidities, HIV and HAART status, Mechanical ventilation(days) and length on ICU stay(days), ICU final diagnosis, Ino-tropic/vasopressor use, Sedation, NEWS score will be run in univariate and multivariate to assess association with mortality.

Trial Locations

Locations (1)

Atumanya Patience; 🇺🇬 Kampala, Uganda