Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care Unit
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 97
- 试验地点
- 1
- 主要终点
- Incidence of Pediatric critical illness polyneuropathy/myopathy
研究概览
简要总结
Intensive Care Unit Acquired Weakness(ICUAW) encompasses a spectrum of disorders characterized by generalized weakness developing after the onset of critical illness. Pediatric data on the incidence of ICUAW is restricted to isolated case reports and case series of no more than five children. Critical illness polyneuropathy is characterized by reduction in compound motor action potential or sensory nerve action potential or both with preserved conduction velocity on electrophysiological studies. These findings can occur very early prior to the onset of clinical features. Given the dearth of data in children on the subject, this study has been planned to evaluate the incidence of critical illness associated polyneuropathy /myopathy in severely sick children admitted.
详细描述
Materials and Methods
Study Setting: Pediatric Intensive Care Unit, Advanced Pediatric Centre, Postgraduate Institute of Medical Educational Research
Study Period: Jan 2016 to Dec 2016
Study design: Prospective Cohort Study
Study Population: Children of 2 years to 12 years of age
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 12 Years(Child)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children admitted in Pediatric Intensive Care Unit for more than 24 hours
- •Pediatric Risk of Mortality (PRISM) score III > 20
排除标准
- •Previous (Eg: Diabetes Mellitus, Systemic Lupus Erythematosus, Dermatomyositis, Spinal Muscular Atrophy) or current neuromuscular disorder (e.g Guillian Barre Syndrome, snake bite, myositis)
- •Use of drugs causing neuromuscular blockade
- •Bilateral Lower limb disorders precluding Nerve Conduction Study or ElectroMyoGraphy (Gross edema, fractures, amputation, plaster casts, open wounds, infections)
- •Children with abnormal electrophysiological studies at baseline examination will be excluded
结局指标
主要结局
Incidence of Pediatric critical illness polyneuropathy/myopathy
时间窗: 1 month
次要结局
未报告次要终点
研究者
Ananthanarayanan
Senior resident
Post Graduate Institute of Medical Education and Research, Chandigarh
