Role of periodontitis in accelerated ageing in HIV-infected patients

Completed

• Conditions: mondgezondheid; HIV infection; periodontitis; 10047438; 10014523

• Registration Number: NL-OMON40726
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

HIV-1 infection
use of combination antiretroviral therapy for >=6 months and last 2 viral loads <40 copies/ml or undetectable

Exclusion Criteria

• Unable to understand spoken and written Dutch or English language
• History of radiation therapy in the head and neck region
• Edentulism

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Independent endpoints: Periodontal Inflamed Surface Area (PISA)<br /><br>Dependent endpoints: markers of immune activation and hemostasis and<br /><br>composition of the oral microbiota.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Content of the oral microbiome as effect modifier of the relationship between<br /><br>the main study parameters.</p><br>