The Impact of Split-belt Treadmill Training to Modulate Freezing-related Gait Deficits and Freezing Episodes in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 52
- 试验地点
- 4
- 主要终点
- Average overground 360 degree turning speed (degrees/s)
研究概览
简要总结
People with Parkinson's disease (PD) often show gait impairments such as, shuffling gait, short steps and gait asymmetry and irregularity. These gait problems are already apparent in the early disease stages, having an immense effect on daily life functioning. Especially Freezing of Gait (FOG), where the patients are not able to initiate or continue their movement despite their intention to do so, is a debilitating problem. It is thought that lack of gait adaptability could be an underlying cause of FOG. With a split-belt treadmill the speed of both legs can be controlled independently, which forces participants to actively adapt their gait to the new situation. In a previous study performed at our lab, it was shown that only one session of split-belt training (SBT), in which the speed of one leg was reduced, improved gait adaptability and other gait features compared to tied-belt training (TBT). Furthermore, overground turning speed improved after only one single training session and this was even retained 24 hours later, indicating training induced long-term potentiation. Since the short-term effects of SBT are promising, the objective of this study is to investigate if 4 weeks of SBT, 3 times a week, has an effect on gait deficits found in individuals with PD, compared to 4-weeks, 3 times a week, of TBT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
The assessors will be single blinded. Participants will be semi-blinded. The participants will be told that they can be assigned to one of the two forms of treadmill training.They do not know the exact content of the training they would receive and what training is given in the other arm.
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of PD according to the recent criteria of the Movement Disorders Society made by a neurologist
- •Participants should be able to walk 5 minutes at a stretch without a walking aid
- •Hoehn & Yahr stage II or III in the ON state of medication
- •Mini Mental State Examination score of 24 or above
- •Participants should have a steady medication schedule at the start of the study (no change in the past month).
- •To be included as a freezer participant a score of at least 1 or higher should be recorded with the New Freezing of Gait Questionnaire.
排除标准
- •Current enrollment in another clinical study which may interfere with the conduction of this study.
- •Orthopedic injuries or other musculoskeletal problems, which could possibly effect balance and/or gait.
- •Unable or unwilling to commit to 4 weeks of training, 3 times a week
- •Participation in walking training in the month prior to the start of the study
- •Other neurological impairments (except PD)
- •Cardiovascular exercise risk factors diagnosed by a doctor
结局指标
主要结局
Average overground 360 degree turning speed (degrees/s)
时间窗: Change in performance between the average overground turning speed from pre to post intervention (i.e. the week after the 4-week training period ended)
Participants will be instructed to turn 360 degrees in alternating directions (clockwise/counterclockwise) for 60 seconds. The instruction is to turn as quickly as possible, while still feeling safe doing this. The average overground turning speed will be determined by the use of APDM Opal accelerometers which will be worn on both feet, wrists and the lower back.
次要结局
- Retention of average overground 360 degree turning speed (degrees/sec)(Change in performance from post-intervention 1 week after the 4-week training period ended (Retest 1) to retention, 5 weeks later (Retest 2).)
- Retention of dual task average overground 360 degree turning speed (degrees/sec)(Change in performance from post-intervention 1 week after the 4-week training period ended (Retest 1) to retention, 5 weeks later (Retest 2).)
- Average dual task overground 360 degree turning speed (degrees/sec)(Change in performance between the average overground turning speed from pre to post intervention (i.e. the week after the 4-week training period ended))