Do patients having major abdominal surgery exhibit significant muscle wasting?

Not Applicable

Completed

• Conditions: Muscle wasting disease (myopenia); Musculoskeletal Diseases; Myopenia

• Registration Number: ISRCTN96363642
• Lead Sponsor: Royal Surrey County Hospital Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-05-06
• Study Completion: 2019-01-31
• Last Update Posted: 29 October 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

Current inclusion criteria as of 26/11/2018:
1. Patients presenting to Royal Surrey County Hospital (RSCH) for elective major abdominal surgery for cancer with predicted duration of surgery of >3 hours, such as resection of pancreas and small bowel or resection of organs of the female reproductive tract
2. Provide informed consent
3. Age =18 years

Previous inclusion criteria:
1. Patients presenting to Royal Surrey County Hospital (RSCH) for elective major abdominal surgery for cancer (e.g. resection of whole/part of colon, rectum, stomach, oesophagus, liver, pancreas and small bowel; or resection of organs of the female reproductive tract) with predicted duration of surgery of >3 hours
2. Provide informed consent
3. Age =18 years

Exclusion Criteria

Current exclusion criteria as of 26/11/2018:
1. Neuromuscular condition
2. Invasively ventilated pre-operatively
3. Recent (<1 month) surgery, other than for the purposes of diagnosis/staging.
4. Unlikely to survive 1 month post-operatively

Previous exclusion criteria:
1. Neuromuscular condition
2. Invasively ventilated pre-op
3. Recent (<1 month) surgery, other than for the purposes of diagnosis/staging.
4. Unlikely to survive 1 month post-operatively
5. Obesity

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Characterise changes in muscle size and strength in patients undergoing major elective abdominal surgery for cancer at 2 stages: pre-operative and at day 7<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Establish the relationship between observed changes in muscle size and strength<br> 2. Establish the clinical sequelae of muscle wasting and weakness in relation to clinical outcomes<br> 3. Elucidate risk factors for muscle wasting and muscle weakness<br> 4. Assess relationship between muscle wasting and weakness<br> 5. Assess recovery of muscle wasting and weakness between hospital discharge and week 6 and to elucidate risk factors for persistent or progressive change<br>