Preemptive Low-dose Epidural Ketamine for Preventing Chronic Post-thoracotomy Pain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 209
- 试验地点
- 1
- 主要终点
- Incidence of pain 3 months after surgery
研究概览
简要总结
Chronic post-thoracotomy pain is the most common long-term complication that occurs after a thoracotomy with a reported incidence of up to 80%. While thoracic epidural analgesia has become the mainstay for managing acute post-thoracotomy pain, its effect on the chronic post-thoracotomy pain seems questionable. The objective of this prospective, double-blinded, randomized, controlled trial was to assess the effect of preemptive low-dose epidural ketamine in addition to preemptive thoracic epidural analgesia on the incidence of chronic post-thoracotomy pain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 19 Years 至 81 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing surgery with a thoracotomy incision
排除标准
- •history of previous thoracic surgery, chronic pain, psychiatric disease, cardiac or vascular disease, neurologic deficits, or contraindications to epidural catheterization such as coagulopathy, or localized or systemic infection
研究组 & 干预措施
ketamine
epidural ketamine added to the patient controlled epidural analgesia regimen
干预措施: Ketamine (Drug)
ketamine free
epidural ketamine NOT added to the patient controlled epidural analgesia regimen
干预措施: ketamine free (Drug)
结局指标
主要结局
Incidence of pain 3 months after surgery
时间窗: 3 months after surgery
次要结局
未报告次要终点