Preemptive Low-dose Epidural Ketamine for Preventing Chronic Post-thoracotomy Pain
Not Applicable
Completed
- Conditions
- Chronic Post-thoracotomy Pain
- Interventions
- Registration Number
- NCT01017393
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
Chronic post-thoracotomy pain is the most common long-term complication that occurs after a thoracotomy with a reported incidence of up to 80%. While thoracic epidural analgesia has become the mainstay for managing acute post-thoracotomy pain, its effect on the chronic post-thoracotomy pain seems questionable. The objective of this prospective, double-blinded, randomized, controlled trial was to assess the effect of preemptive low-dose epidural ketamine in addition to preemptive thoracic epidural analgesia on the incidence of chronic post-thoracotomy pain.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 209
Inclusion Criteria
- Patients undergoing surgery with a thoracotomy incision
Exclusion Criteria
- history of previous thoracic surgery, chronic pain, psychiatric disease, cardiac or vascular disease, neurologic deficits, or contraindications to epidural catheterization such as coagulopathy, or localized or systemic infection
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description ketamine free ketamine free epidural ketamine NOT added to the patient controlled epidural analgesia regimen ketamine Ketamine epidural ketamine added to the patient controlled epidural analgesia regimen
- Primary Outcome Measures
Name Time Method Incidence of pain 3 months after surgery 3 months after surgery
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of