Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study
- Registration Number
- NCT02570230
- Lead Sponsor
- Mahidol University
- Brief Summary
Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills. Spinal morphine is alternative simple method with less efficacy. Adding low dose ketamine during intraoperative may be helpful in postoperative pain relief.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
- ASA physical status 1-3
- elective thoracotomy
- can operate patient-controlled analgesia (PCA) machine
Exclusion Criteria
patient with history of
- allergy to morphine or ketamine
- contraindicate to ketamine
- remain intubated in the postoperative period
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control NSS NSS infusion Ketamine Ketamine Ketamine 0.2 mg/kg/hr intravenous infusion
- Primary Outcome Measures
Name Time Method Time to first trigger of morphine 24 hours Time to first trigger of morphine
- Secondary Outcome Measures
Name Time Method 24-hr morphine consumption 24 hours 24-hr morphine consumption
NRS score at 6, 24 hours 24 hours NRS score (0-10) was assessed at at 6, 24 hours postoperative
Incidence of nausea and vomiting 24 hours Incidence of nausea and vomiting
Trial Locations
- Locations (1)
Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University
🇹ðŸ‡Bangkok, Thailand