Adipogenic Capacity as a Mediator of Weight Gain

Not Applicable

• Conditions: Obesity
• Interventions: Other: Very Low Energy Diet (VLED); Other: Weight maintenance

• Registration Number: NCT01015508
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

To demonstrate differences in response of subjects with a high, low or medium predisposition for weight regain after weight reduction in terms of: body composition; energy expenditure; physical activity; and adipogenic capacity.

Detailed Description

The risk for weight regain after weight loss is a major problem for the current obesity treatments, and is largely genetically determined. It is believed that an elucidation of the genetic component in the prognosis of weight management could assist in the development of more effective and individually tailored treatments. However, current research on the genetic component of weight management, and in particular weight regain, is still limited and data available are sometimes inconsistent. The current research proposal aims to identify groups with a high, low or medium predisposition for weight regain, based on a genetic profile and to demonstrate differences in the response of these subjects to a weight maintenance period after weight reduction in terms of body composition, physical activity, adipogenic capacity and energy expenditure.

Study Timeline

• Study First Submitted: 2009-11-17
• Study First Submitted QC: 2009-11-17
• Study First Posted: 2009-11-18
• Study Start: 2010-02
• Status Verified: 2012-10
• Last Update Submitted: 2012-10-24
• Last Update Posted: 2012-10-25
• Primary Completion: 2012-11
• Study Completion: 2012-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• BMI 28-35
• healthy, no medication
• no smoking
• stable weight (no weight loss/gain > 5kg in 3 months prior to study)

Exclusion Criteria

• 28< BMI >35
• use of medication
• smoking
• weight loss/gain > 5kg in 3 months prior to study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High predisposition	Very Low Energy Diet (VLED)	High predisposition for weight regain
High predisposition	Weight maintenance	High predisposition for weight regain
low predisposition	Very Low Energy Diet (VLED)	low predisposition for weight regain
low predisposition	Weight maintenance	low predisposition for weight regain
Medium predisposition	Very Low Energy Diet (VLED)	Medium predisposition for weight regain
Medium predisposition	Weight maintenance	Medium predisposition for weight regain

Primary Outcome Measures

Name	Time	Method
Energy expenditure	0, 2 and 12 months

Secondary Outcome Measures

Name	Time	Method
Adipogenic capacity, Physical activity and body composition	0, 2 and 12 months

Trial Locations

Locations (1)

Dept. of Human Biology (Maastricht University); 🇳🇱 Maastricht, Limburg, Netherlands