eutrophil dysfunction and sepsis in ICU patients.

Completed

• Conditions: Trauma en acute post-operatieve patiënten; multiple organ failure; Sepsis; 10027665; 10004018

• Registration Number: NL-OMON31712
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 160

Inclusion Criteria

1) Patients admitted to the intensive care unit
2) After sugery or major trauma
3) Age above 18
4) Expected stay > 2 days

Exclusion Criteria

Immunological compromised - e.g. patients treated with steroids and/or cytostatic drugs

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary variables:<br /><br>- Degree of inactivity of neutrophils<br /><br><br /><br>Primary outcome:<br /><br>- Development of inflammatory-induced complications (sepsis/septic<br /><br>shock/(multiple) organ failure)<br /><br>(According to the SIRS/Sepsis criteria)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secundary variables:<br /><br>- Normalization of neutrophil receptor profile<br /><br>- Percentage of cells in specific populations of neutrophils.<br /><br><br /><br>Secundary outcome:<br /><br>- Development of inflammatory-induced complications (sepsis/septic<br /><br>shock/(multiple) organ failure)<br /><br>- Severity of illness during the intensive care period<br /><br>(According to disease severity on admission: APACHE II Score)<br /><br>(According to the maximal SOFA score during admission)</p><br>